Tumor genetics and their outcomes on surgery and survival

Jeff Ehresman, Chetan Bettegowda

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The current field of neurooncology has discovered many genetic markers found in intracranial gliomas. Studies have genetically characterized gliomas and subsequently compared outcomes and response to treatments. The gliomas assessed in this chapter are grouped into grade II and III astrocytomas, grade II and III oligodendrogliomas, grade IV astrocytomas (glioblastomas), and midline gliomas. While the associated outcomes of many genes are outlined in this chapter, the IDH1/2 mutations in grade II/III astrocytomas are currently the only genetic evidence of better outcomes after surgical resection. Glioblastomas can be divided into four subtypes: classical, proneural, mesenchymal, and neural. Each subtype has its own fairly distinct genetic signature with similar outcomes. Lastly, genetic markers of midline gliomas are now being elucidated, although prognosis remains poor in these tumors. While the search for genetic markers in glioma will continue to progress neurooncology, it is important to assess and utilize our current information.

Original languageEnglish (US)
Title of host publicationComprehensive Overview of Modern Surgical Approaches to Intrinsic Brain Tumors
PublisherElsevier
Pages191-203
Number of pages13
ISBN (Electronic)9780128117835
ISBN (Print)9780128117842
DOIs
StatePublished - Jan 1 2019

Keywords

  • Genetic mutation
  • Intracranial glioma
  • Neurooncology
  • Outcomes
  • Survival

ASJC Scopus subject areas

  • Medicine(all)

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