Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors

Akash Nanda, Baktiar Karim, Zhongsheng Peng, Guosheng Liu, Weiping Qiu, Christine Gan, Bert Vogelstein, Brad St Croix, Kenneth W. Kinzler, David L. Huso

Research output: Contribution to journalArticle

Abstract

Tumor endothelial marker 1 (Tem1; endosialin) is the prototypical member of a family of genes expressed in the stroma of tumors. To assess the functional role of Tem1, we disrupted the Tem1 gene in mice by targeted homologous recombination. Tem1-/- mice were healthy, their wound healing was normal, and tumors grew normally when implanted in s.c. sites. However, there was a striking reduction in tumor growth, invasiveness, and metastasis after transplantation of tumors to abdominal sites in mice without functional Tem1 genes. These data indicate that the stroma can control tumor aggressiveness and that this control varies with anatomic site. Therefore, they have significant implications for the mechanisms underlying tumor invasiveness and for models that evaluate this process.

Original languageEnglish (US)
Pages (from-to)3351-3356
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number9
DOIs
StatePublished - Feb 28 2006

Keywords

  • Angiogenesis
  • Endosialin
  • Metastasis
  • Stroma
  • Tumor invasiveness

ASJC Scopus subject areas

  • General

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