Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors

Akash Nanda, Baktiar Karim, Zhongsheng Peng, Guosheng Liu, Weiping Qiu, Christine Gan, Bert Vogelstein, Brad St Croix, Kenneth W Kinzler, David L. Huso

Research output: Contribution to journalArticle

Abstract

Tumor endothelial marker 1 (Tem1; endosialin) is the prototypical member of a family of genes expressed in the stroma of tumors. To assess the functional role of Tem1, we disrupted the Tem1 gene in mice by targeted homologous recombination. Tem1-/- mice were healthy, their wound healing was normal, and tumors grew normally when implanted in s.c. sites. However, there was a striking reduction in tumor growth, invasiveness, and metastasis after transplantation of tumors to abdominal sites in mice without functional Tem1 genes. These data indicate that the stroma can control tumor aggressiveness and that this control varies with anatomic site. Therefore, they have significant implications for the mechanisms underlying tumor invasiveness and for models that evaluate this process.

Original languageEnglish (US)
Pages (from-to)3351-3356
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number9
DOIs
StatePublished - Feb 28 2006

Fingerprint

Tumor Biomarkers
Growth
Neoplasms
Genes
Homologous Recombination
Wound Healing
Transplantation
Neoplasm Metastasis

Keywords

  • Angiogenesis
  • Endosialin
  • Metastasis
  • Stroma
  • Tumor invasiveness

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors. / Nanda, Akash; Karim, Baktiar; Peng, Zhongsheng; Liu, Guosheng; Qiu, Weiping; Gan, Christine; Vogelstein, Bert; Croix, Brad St; Kinzler, Kenneth W; Huso, David L.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 9, 28.02.2006, p. 3351-3356.

Research output: Contribution to journalArticle

Nanda, Akash ; Karim, Baktiar ; Peng, Zhongsheng ; Liu, Guosheng ; Qiu, Weiping ; Gan, Christine ; Vogelstein, Bert ; Croix, Brad St ; Kinzler, Kenneth W ; Huso, David L. / Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors. In: Proceedings of the National Academy of Sciences of the United States of America. 2006 ; Vol. 103, No. 9. pp. 3351-3356.
@article{538e99837f774c3bbd991385a6ee1c69,
title = "Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors",
abstract = "Tumor endothelial marker 1 (Tem1; endosialin) is the prototypical member of a family of genes expressed in the stroma of tumors. To assess the functional role of Tem1, we disrupted the Tem1 gene in mice by targeted homologous recombination. Tem1-/- mice were healthy, their wound healing was normal, and tumors grew normally when implanted in s.c. sites. However, there was a striking reduction in tumor growth, invasiveness, and metastasis after transplantation of tumors to abdominal sites in mice without functional Tem1 genes. These data indicate that the stroma can control tumor aggressiveness and that this control varies with anatomic site. Therefore, they have significant implications for the mechanisms underlying tumor invasiveness and for models that evaluate this process.",
keywords = "Angiogenesis, Endosialin, Metastasis, Stroma, Tumor invasiveness",
author = "Akash Nanda and Baktiar Karim and Zhongsheng Peng and Guosheng Liu and Weiping Qiu and Christine Gan and Bert Vogelstein and Croix, {Brad St} and Kinzler, {Kenneth W} and Huso, {David L.}",
year = "2006",
month = "2",
day = "28",
doi = "10.1073/pnas.0511306103",
language = "English (US)",
volume = "103",
pages = "3351--3356",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "9",

}

TY - JOUR

T1 - Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors

AU - Nanda, Akash

AU - Karim, Baktiar

AU - Peng, Zhongsheng

AU - Liu, Guosheng

AU - Qiu, Weiping

AU - Gan, Christine

AU - Vogelstein, Bert

AU - Croix, Brad St

AU - Kinzler, Kenneth W

AU - Huso, David L.

PY - 2006/2/28

Y1 - 2006/2/28

N2 - Tumor endothelial marker 1 (Tem1; endosialin) is the prototypical member of a family of genes expressed in the stroma of tumors. To assess the functional role of Tem1, we disrupted the Tem1 gene in mice by targeted homologous recombination. Tem1-/- mice were healthy, their wound healing was normal, and tumors grew normally when implanted in s.c. sites. However, there was a striking reduction in tumor growth, invasiveness, and metastasis after transplantation of tumors to abdominal sites in mice without functional Tem1 genes. These data indicate that the stroma can control tumor aggressiveness and that this control varies with anatomic site. Therefore, they have significant implications for the mechanisms underlying tumor invasiveness and for models that evaluate this process.

AB - Tumor endothelial marker 1 (Tem1; endosialin) is the prototypical member of a family of genes expressed in the stroma of tumors. To assess the functional role of Tem1, we disrupted the Tem1 gene in mice by targeted homologous recombination. Tem1-/- mice were healthy, their wound healing was normal, and tumors grew normally when implanted in s.c. sites. However, there was a striking reduction in tumor growth, invasiveness, and metastasis after transplantation of tumors to abdominal sites in mice without functional Tem1 genes. These data indicate that the stroma can control tumor aggressiveness and that this control varies with anatomic site. Therefore, they have significant implications for the mechanisms underlying tumor invasiveness and for models that evaluate this process.

KW - Angiogenesis

KW - Endosialin

KW - Metastasis

KW - Stroma

KW - Tumor invasiveness

UR - http://www.scopus.com/inward/record.url?scp=33644777599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644777599&partnerID=8YFLogxK

U2 - 10.1073/pnas.0511306103

DO - 10.1073/pnas.0511306103

M3 - Article

VL - 103

SP - 3351

EP - 3356

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 9

ER -