Tumor cells and memory T cells converge at glycolysis: Therapeutic implications

Swathi Karthikeyan, Jean Francois Geschwind, Shanmugasundaram Ganapathy-Kanniappan

Research output: Contribution to journalArticle

Abstract

In the immune system, activation of naïve T (Tn) cells into effector T cells (Teff) involves a metabolic switch to glycolysis to promote rapid proliferation and differentiation. In the October issue of The Journal of Clinical Investigation, Sukumar et al. have demonstrated that in CD8+ memory T (Tems) cells glycolytic phenotype contributes to the shortened lifespan of Tems. Conversely, inhibition of glycolysis in Tems not only extended their viability but also augmented desirable properties. Notably, they also demonstrate that glycolytic inhibition during the ex vivo clonal expansion of tumorspecific Tems enhanced their antitumor function. Overall, the data suggest that an antiglycolytic strategy targeting the Tems could enhance antitumor immune response. On the other hand, cancer cells have long been known to exhibit metabolic reprogramming which involves a shift toward glycolysis (the conversion of glucose into lactate) to facilitate uninterrupted growth. Interestingly, antiglycolytic treatment of cancer cells has been known to trigger antitumor immune response as well. Taken together, it is probable that a strategy involving concurrent inhibition of glycolysis in tumor cells and Tems could promote a dual attack on cancer by inducing an effective antitumor immune response and an immunogenic chemotherapy.

Original languageEnglish (US)
Pages (from-to)483-485
Number of pages3
JournalCancer Biology and Therapy
Volume15
Issue number5
DOIs
StatePublished - May 2014

Keywords

  • Cancer
  • Chemotherapy
  • Glycolysis
  • Immunotherapy
  • T cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

Fingerprint Dive into the research topics of 'Tumor cells and memory T cells converge at glycolysis: Therapeutic implications'. Together they form a unique fingerprint.

  • Cite this