Tumor cell origin of histaminase activity in ascites fluid from patients with ovarian carcinoma

David S Ettinger, N. B. Rosenshein, T. H. Parmley, G. Mendelsohn, Stephen B Baylin

Research output: Contribution to journalArticle


The authors have demonstrated by tissue assay and immunohistochemical techniques that tumor cells appear to be the source of the increased histaminase activity found in 60% of ascitic fluids from patients with ovarian carcinoma. The histaminase activity in 64% of tumor tissues studied was >100 U/g of tissue, a value higher than that for normal tissues other than kidney and intestine. The presence of elevated ascitic fluid histaminase activity (>3.5 U/ml) correlates with the presence of high histaminase activity in tumor tissue. Histaminase activity is higher in ascitic fluid from the patients than it is in their plasma, probably reflecting the direct entry of histaminase into the peritoneal cavity.

Original languageEnglish (US)
Pages (from-to)2568-2572
Number of pages5
Issue number10
StatePublished - 1980


ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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