Tumor cell origin of histaminase activity in ascites fluid from patients with ovarian carcinoma

David S. Ettinger; Neil B. Rosenshein; Tim H. Parmley; Geoffrey Mendelsohn; Stephen B. Baylin

doi:10.1002/1097-0142(19800515)45:10<2568::AID-CNCR2820451016>3.0.CO;2-P

Tumor cell origin of histaminase activity in ascites fluid from patients with ovarian carcinoma

David S. Ettinger, Neil B. Rosenshein, Tim H. Parmley, Geoffrey Mendelsohn, Stephen B. Baylin

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We have demonstrated by tissue assay and immunohistochemical techniques that tumor cells appear to be the source of the increased histaminase activity found in 60% of ascitic fluids from patients with ovarian carcinoma. The histaminase activity in 64% of tumor tissues studied was >100 U/g of tissue, a value higher than that for normal tissues other than kidney and intestine. The presence of elevated ascitic fluid histaminase activity (>3.5 U/ml) correlates with the presence of high histaminase activity in tumor tissue. Histaminase activity is higher in ascitic fluid from the patients than it is in their plasma, probably reflecting the direct entry of histaminase into the peritoneal cavity.

Original language	English (US)
Pages (from-to)	2568-2572
Number of pages	5
Journal	Cancer
Volume	45
Issue number	10
DOIs	https://doi.org/10.1002/1097-0142(19800515)45:10<2568::AID-CNCR2820451016>3.0.CO;2-P
State	Published - May 15 1980

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19800515)45:10<2568::AID-CNCR2820451016>3.0.CO;2-P

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title = "Tumor cell origin of histaminase activity in ascites fluid from patients with ovarian carcinoma",

abstract = "We have demonstrated by tissue assay and immunohistochemical techniques that tumor cells appear to be the source of the increased histaminase activity found in 60% of ascitic fluids from patients with ovarian carcinoma. The histaminase activity in 64% of tumor tissues studied was >100 U/g of tissue, a value higher than that for normal tissues other than kidney and intestine. The presence of elevated ascitic fluid histaminase activity (>3.5 U/ml) correlates with the presence of high histaminase activity in tumor tissue. Histaminase activity is higher in ascitic fluid from the patients than it is in their plasma, probably reflecting the direct entry of histaminase into the peritoneal cavity.",

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AU - Ettinger, David S.

AU - Rosenshein, Neil B.

AU - Parmley, Tim H.

AU - Mendelsohn, Geoffrey

AU - Baylin, Stephen B.

PY - 1980/5/15

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N2 - We have demonstrated by tissue assay and immunohistochemical techniques that tumor cells appear to be the source of the increased histaminase activity found in 60% of ascitic fluids from patients with ovarian carcinoma. The histaminase activity in 64% of tumor tissues studied was >100 U/g of tissue, a value higher than that for normal tissues other than kidney and intestine. The presence of elevated ascitic fluid histaminase activity (>3.5 U/ml) correlates with the presence of high histaminase activity in tumor tissue. Histaminase activity is higher in ascitic fluid from the patients than it is in their plasma, probably reflecting the direct entry of histaminase into the peritoneal cavity.

AB - We have demonstrated by tissue assay and immunohistochemical techniques that tumor cells appear to be the source of the increased histaminase activity found in 60% of ascitic fluids from patients with ovarian carcinoma. The histaminase activity in 64% of tumor tissues studied was >100 U/g of tissue, a value higher than that for normal tissues other than kidney and intestine. The presence of elevated ascitic fluid histaminase activity (>3.5 U/ml) correlates with the presence of high histaminase activity in tumor tissue. Histaminase activity is higher in ascitic fluid from the patients than it is in their plasma, probably reflecting the direct entry of histaminase into the peritoneal cavity.

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Tumor cell origin of histaminase activity in ascites fluid from patients with ovarian carcinoma

Abstract

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