Tumor cell origin of histaminase activity in ascites fluid from patients with ovarian carcinoma

David S. Ettinger, Neil B. Rosenshein, Tim H. Parmley, Geoffrey Mendelsohn, Stephen B. Baylin

Research output: Contribution to journalArticlepeer-review

Abstract

We have demonstrated by tissue assay and immunohistochemical techniques that tumor cells appear to be the source of the increased histaminase activity found in 60% of ascitic fluids from patients with ovarian carcinoma. The histaminase activity in 64% of tumor tissues studied was >100 U/g of tissue, a value higher than that for normal tissues other than kidney and intestine. The presence of elevated ascitic fluid histaminase activity (>3.5 U/ml) correlates with the presence of high histaminase activity in tumor tissue. Histaminase activity is higher in ascitic fluid from the patients than it is in their plasma, probably reflecting the direct entry of histaminase into the peritoneal cavity.

Original languageEnglish (US)
Pages (from-to)2568-2572
Number of pages5
JournalCancer
Volume45
Issue number10
DOIs
StatePublished - May 15 1980

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Tumor cell origin of histaminase activity in ascites fluid from patients with ovarian carcinoma'. Together they form a unique fingerprint.

Cite this