Tumor cell growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11

Minoru Koi, Laura A. Johnson, Linda M. Kalikin, Peter F.R. Little, Yusuke Nakamura, Andrew P. Feinberg

Research output: Contribution to journalArticlepeer-review

Abstract

A fundamental problem in the identification and isolation of tumor suppressor and other growth-inhibiting genes is the loss of power of genetic complementation at the subchromosomal level. A direct genetic strategy was developed to isolate subchromosomal transferable fragments (STFs) from any chromosome, each containing a selectable marker within the human DNA, that could be transferred to any mammalian cell. As a test of the method, several overlapping STFs from 11p15 were shown to cause in vitro growth arrest of rhabdomyosarcoma cells. This activity mapped between the β-globin and insulin genes.

Original languageEnglish (US)
Pages (from-to)361-364
Number of pages4
JournalScience
Volume260
Issue number5106
DOIs
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • General

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