Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

Haidong Dong, Scott E. Strome, Diva R. Salomao, Hideto Tamura, Fumiya Hirano, Dallas B. Flies, Patrick C. Roche, Jun Lu, Gefeng Zhu, Koji Tamada, Vanda A. Lennon, Esteban Cells, Lieping Chen

Research output: Contribution to journalArticle

Abstract

B7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in the regulation of cellular and humoral immune responses through the PD-1 receptor on activated T and B cells. We report here that, except for cells of the macrophage lineage, normal human tissues do not express B7-H1. In contrast, B7-H1 is abundant in human carcinomas of lung, ovary and colon and in melanomas. The pro-inflammatory cytokine interferon-γ upregulates B7-H1 on the surface of tumor cell lines. Cancer cell-associated B7-H1 increases apoptosis of antigen-specific human T-cell clones in vitro, and the apoptotic effect of B7-H1 is mediated largely by one or more receptors other than PD-1. In addition, expression of B7-H1 on mouse P815 tumor increases apoptosis of activated tumor-reactive T cells and promotes the growth of highly immunogenic B7-H1 tumors in vivo. These findings have implications for the design of T cell-based cancer immunotherapy.

Original languageEnglish (US)
Pages (from-to)793-800
Number of pages8
JournalNature Medicine
Volume8
Issue number8
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Immune Evasion
T-cells
Tumors
Apoptosis
Programmed Cell Death 1 Receptor
T-Lymphocytes
Cells
Neoplasms
B7 Antigens
Macrophages
Interferons
Cell Lineage
Humoral Immunity
Tumor Cell Line
Cellular Immunity
Immunotherapy
Tissue
Cytokines
Ovary
Melanoma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., ... Chen, L. (2002). Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nature Medicine, 8(8), 793-800. https://doi.org/10.1038/nm730

Tumor-associated B7-H1 promotes T-cell apoptosis : A potential mechanism of immune evasion. / Dong, Haidong; Strome, Scott E.; Salomao, Diva R.; Tamura, Hideto; Hirano, Fumiya; Flies, Dallas B.; Roche, Patrick C.; Lu, Jun; Zhu, Gefeng; Tamada, Koji; Lennon, Vanda A.; Cells, Esteban; Chen, Lieping.

In: Nature Medicine, Vol. 8, No. 8, 2002, p. 793-800.

Research output: Contribution to journalArticle

Dong, H, Strome, SE, Salomao, DR, Tamura, H, Hirano, F, Flies, DB, Roche, PC, Lu, J, Zhu, G, Tamada, K, Lennon, VA, Cells, E & Chen, L 2002, 'Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion', Nature Medicine, vol. 8, no. 8, pp. 793-800. https://doi.org/10.1038/nm730
Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB et al. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nature Medicine. 2002;8(8):793-800. https://doi.org/10.1038/nm730
Dong, Haidong ; Strome, Scott E. ; Salomao, Diva R. ; Tamura, Hideto ; Hirano, Fumiya ; Flies, Dallas B. ; Roche, Patrick C. ; Lu, Jun ; Zhu, Gefeng ; Tamada, Koji ; Lennon, Vanda A. ; Cells, Esteban ; Chen, Lieping. / Tumor-associated B7-H1 promotes T-cell apoptosis : A potential mechanism of immune evasion. In: Nature Medicine. 2002 ; Vol. 8, No. 8. pp. 793-800.
@article{ec1d705cf8064f26b80a8b075c86ae01,
title = "Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion",
abstract = "B7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in the regulation of cellular and humoral immune responses through the PD-1 receptor on activated T and B cells. We report here that, except for cells of the macrophage lineage, normal human tissues do not express B7-H1. In contrast, B7-H1 is abundant in human carcinomas of lung, ovary and colon and in melanomas. The pro-inflammatory cytokine interferon-γ upregulates B7-H1 on the surface of tumor cell lines. Cancer cell-associated B7-H1 increases apoptosis of antigen-specific human T-cell clones in vitro, and the apoptotic effect of B7-H1 is mediated largely by one or more receptors other than PD-1. In addition, expression of B7-H1 on mouse P815 tumor increases apoptosis of activated tumor-reactive T cells and promotes the growth of highly immunogenic B7-H1 tumors in vivo. These findings have implications for the design of T cell-based cancer immunotherapy.",
author = "Haidong Dong and Strome, {Scott E.} and Salomao, {Diva R.} and Hideto Tamura and Fumiya Hirano and Flies, {Dallas B.} and Roche, {Patrick C.} and Jun Lu and Gefeng Zhu and Koji Tamada and Lennon, {Vanda A.} and Esteban Cells and Lieping Chen",
year = "2002",
doi = "10.1038/nm730",
language = "English (US)",
volume = "8",
pages = "793--800",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - Tumor-associated B7-H1 promotes T-cell apoptosis

T2 - A potential mechanism of immune evasion

AU - Dong, Haidong

AU - Strome, Scott E.

AU - Salomao, Diva R.

AU - Tamura, Hideto

AU - Hirano, Fumiya

AU - Flies, Dallas B.

AU - Roche, Patrick C.

AU - Lu, Jun

AU - Zhu, Gefeng

AU - Tamada, Koji

AU - Lennon, Vanda A.

AU - Cells, Esteban

AU - Chen, Lieping

PY - 2002

Y1 - 2002

N2 - B7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in the regulation of cellular and humoral immune responses through the PD-1 receptor on activated T and B cells. We report here that, except for cells of the macrophage lineage, normal human tissues do not express B7-H1. In contrast, B7-H1 is abundant in human carcinomas of lung, ovary and colon and in melanomas. The pro-inflammatory cytokine interferon-γ upregulates B7-H1 on the surface of tumor cell lines. Cancer cell-associated B7-H1 increases apoptosis of antigen-specific human T-cell clones in vitro, and the apoptotic effect of B7-H1 is mediated largely by one or more receptors other than PD-1. In addition, expression of B7-H1 on mouse P815 tumor increases apoptosis of activated tumor-reactive T cells and promotes the growth of highly immunogenic B7-H1 tumors in vivo. These findings have implications for the design of T cell-based cancer immunotherapy.

AB - B7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in the regulation of cellular and humoral immune responses through the PD-1 receptor on activated T and B cells. We report here that, except for cells of the macrophage lineage, normal human tissues do not express B7-H1. In contrast, B7-H1 is abundant in human carcinomas of lung, ovary and colon and in melanomas. The pro-inflammatory cytokine interferon-γ upregulates B7-H1 on the surface of tumor cell lines. Cancer cell-associated B7-H1 increases apoptosis of antigen-specific human T-cell clones in vitro, and the apoptotic effect of B7-H1 is mediated largely by one or more receptors other than PD-1. In addition, expression of B7-H1 on mouse P815 tumor increases apoptosis of activated tumor-reactive T cells and promotes the growth of highly immunogenic B7-H1 tumors in vivo. These findings have implications for the design of T cell-based cancer immunotherapy.

UR - http://www.scopus.com/inward/record.url?scp=18544380239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18544380239&partnerID=8YFLogxK

U2 - 10.1038/nm730

DO - 10.1038/nm730

M3 - Article

C2 - 12091876

AN - SCOPUS:18544380239

VL - 8

SP - 793

EP - 800

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

IS - 8

ER -