Tumor antigen presentation: Changing the rules

Todd D. Armstrong, Beth A. Pulaski, Suzanne Ostrand-Rosenberg

Research output: Contribution to journalArticlepeer-review

Abstract

Cell-based tumor vaccines have been developed on the basis of the hypothesis that tumor cells can be genetically modified to present antigen to T lymphocytes directly. Contrary to expectations, cross-priming is the predominant pathway for activation of tumor-specific CD8+ T cells, while direct presentation of antigen dominates activation of tumor-specific CD4+ T cells. These results pose interesting paradoxes for the generation of immune responses, and have definite implications for the development of anti-cancer vaccines.

Original languageEnglish (US)
Pages (from-to)70-74
Number of pages5
JournalCancer Immunology Immunotherapy
Volume46
Issue number2
DOIs
StatePublished - May 1 1998

Keywords

  • Cell-based cancer vaccines
  • Cross- priming
  • Immuno herapy
  • MHC class II
  • Tumor antigen presentation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research

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