TU‐D‐351‐01: Image‐Guided Therapies: From Fundamentals to New Frontiers

Concurrent advances in medical imaging, therapeutics, and understanding the biological basis of disease progression and treatment response point convincingly to a transformative approach to medical interventions in the decades ahead. Such interventions are marked by a dramatic increase in the utilization of image information from multiple modalities and demand accurate coregistration of structural and functional information across a broad range of spatial and temporal scales. The scope of advanced therapeutic approaches enabled by such advances is broad, ranging from high‐precision image‐guided radiation therapy and surgery to minimally invasive target ablation, cell‐based therapies, and other forms of novel therapeutics. Moreover, the information acquired during the course of information will drive patterns of therapy delivery that are increasingly adaptive and patient‐specific. This symposium focuses on the scientific principles of imaging, guidance, treatment delivery, and feedback / adaptation in the context of advanced medical interventions and looks ahead to new technologies being developed for novel image‐guided therapies. Four expert speakers have been invited to present on topics central to such advancement: Dr. Siewerdsen will discuss principles of imaging performance, imaging task, and new imaging technologies; Dr. West will address principles of geometry, registration, and uncertainty (e.g., target registration error) in relation to real‐time tracking and navigation; Dr. Sherar will discuss a broad spectrum of technologies for therapeutic delivery, including physical, molecular, chemical, and cellular means by which a therapeutic insult can be delivered to disease under image guidance; finally, Dr. Yan will describe principles of feedback and control in the development of adapative therapies. Together, these topics present a “closed‐loop” in issues of imaging, navigation, therapy delivery, and adaptation that are central to the advancement of image‐guided interventions.