Tubulpgenesis in Drosophila: A requirement for the trachealess gene product

Daniel D. Isaac, Deborah J. Andrew

Research output: Contribution to journalArticle

Abstract

The trachealess (trh) gene of Drosophila is requited for embryonic tube formation. In trh mutants, tube-forming cells of the salivary gland, trachea, and filzkörper fail to invaginate to form tubes and remain on the embryo surface. We identified a P-element insertion that disrupts trh function and used the insert to clone and characterize trh. trh is expressed in the salivary duct, trachea, and filzköper primordia, and expression persists in these cells throughout embryogenesis. trh expression in the salivary duct is controlled by the homeotic gene, Sex combs reduced (Scr), and by another salivary gland gene, fork head (fkh). trh is homologous to two transcription factors: the human hypoxia-inducible factor-1α and the Drosophila Single-minded protein.

Original languageEnglish (US)
Pages (from-to)103-117
Number of pages15
JournalGenes and Development
Volume10
Issue number1
DOIs
StatePublished - Jan 1 1996

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Keywords

  • Drosophila
  • Trachealess gene
  • Transcription factors
  • Tubulogenesis

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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