Tubulointerstitial Nephritis

Research output: Contribution to journalReview article

Abstract

Tubulointerstitial nephritis (TIN) is a cause of acute kidney injury in children characterized histologically by an inflammatory cell infiltrate in the kidney interstitium. The most common causes of TIN in children include medications, infections, inflammatory disorders, and genetic conditions. TIN typically presents with nonoliguric acute kidney injury and may be associated with systemic symptoms, including fever, rash, and eosinophilia. The long-term prognosis is generally favorable, with full kidney recovery; however, some patients may develop progressive chronic kidney disease. Immunosuppressive therapy may be indicated for severe or prolonged disease.

Original languageEnglish (US)
Pages (from-to)111-119
Number of pages9
JournalPediatric Clinics of North America
Volume66
Issue number1
DOIs
StatePublished - Feb 1 2019

Fingerprint

Interstitial Nephritis
Acute Kidney Injury
Kidney
Inborn Genetic Diseases
Eosinophilia
Immunosuppressive Agents
Exanthema
Chronic Renal Insufficiency
Fever
Infection
Therapeutics

Keywords

  • Acute interstitial nephritis
  • Acute kidney injury
  • Tubulointerstitial nephritis
  • Tubulointerstitial nephritis with uveitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Tubulointerstitial Nephritis. / Ruebner, Rebecca; Fadrowski, Jeffrey J.

In: Pediatric Clinics of North America, Vol. 66, No. 1, 01.02.2019, p. 111-119.

Research output: Contribution to journalReview article

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AB - Tubulointerstitial nephritis (TIN) is a cause of acute kidney injury in children characterized histologically by an inflammatory cell infiltrate in the kidney interstitium. The most common causes of TIN in children include medications, infections, inflammatory disorders, and genetic conditions. TIN typically presents with nonoliguric acute kidney injury and may be associated with systemic symptoms, including fever, rash, and eosinophilia. The long-term prognosis is generally favorable, with full kidney recovery; however, some patients may develop progressive chronic kidney disease. Immunosuppressive therapy may be indicated for severe or prolonged disease.

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