TY - JOUR
T1 - Tubulin Polymerization Promoting Protein (TPPP) gene methylation and corpus callosum measures in maltreated children
AU - de Araújo, Célia Maria
AU - Hudziak, James
AU - Crocetti, Deana
AU - Wymbs, Nicholas F.
AU - Montalvo-Ortiz, Janitza L.
AU - Orr, Catherine
AU - Albaugh, Matthew D.
AU - Althoff, Robert R.
AU - O'Loughlin, Kerry
AU - Holbrook, Hannah
AU - Garavan, Hugh
AU - Yang, Bao Zhu
AU - Mostofsky, Stewart
AU - Jackowski, Andrea
AU - Lee, Richard S.
AU - Gelernter, Joel
AU - Kaufman, Joan
N1 - Publisher Copyright:
© 2020
PY - 2020/4/30
Y1 - 2020/4/30
N2 - The goal of the current study was to evaluate the impact of Tubulin Polymerization Promoting Protein (TPPP) methylation on structural and fractional anisotropy (FA) corpus callosum (CC) measures. TPPP is involved in the development of white matter tracts in the brain and was implicated in stress-related psychiatric disorders in an unbiased whole epigenome methylation study. The cohort included 63 participants (11.73 y/o ±1.91) from a larger study investigating risk and resilience in maltreated children. Voxel-based morphometry (VBM) was used to process the structural data, fractional anisotropy (FA) was determined using an atlas-based approach, and DNA specimens were derived from saliva in two batches using the 450 K (N = 39) and 850 K (N = 24) Illumina arrays, with the data from each batch analyzed separately. After controlling for multiple comparisons and relevant covariates (e.g., demographics, brain volume, cell composition, 3 PCs), 850 K derived TPPP methylation values, in interaction with a dimensional measure of children's trauma experiences, predicted left and right CC body volumes and genu, body and splenium FA (p <.007, all comparisons). The findings in the splenium replicated in subjects with the 450 K data. The results extend prior investigations and suggest a role for TPPP in brain changes associated with stress-related psychiatric disorders.
AB - The goal of the current study was to evaluate the impact of Tubulin Polymerization Promoting Protein (TPPP) methylation on structural and fractional anisotropy (FA) corpus callosum (CC) measures. TPPP is involved in the development of white matter tracts in the brain and was implicated in stress-related psychiatric disorders in an unbiased whole epigenome methylation study. The cohort included 63 participants (11.73 y/o ±1.91) from a larger study investigating risk and resilience in maltreated children. Voxel-based morphometry (VBM) was used to process the structural data, fractional anisotropy (FA) was determined using an atlas-based approach, and DNA specimens were derived from saliva in two batches using the 450 K (N = 39) and 850 K (N = 24) Illumina arrays, with the data from each batch analyzed separately. After controlling for multiple comparisons and relevant covariates (e.g., demographics, brain volume, cell composition, 3 PCs), 850 K derived TPPP methylation values, in interaction with a dimensional measure of children's trauma experiences, predicted left and right CC body volumes and genu, body and splenium FA (p <.007, all comparisons). The findings in the splenium replicated in subjects with the 450 K data. The results extend prior investigations and suggest a role for TPPP in brain changes associated with stress-related psychiatric disorders.
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U2 - 10.1016/j.pscychresns.2020.111058
DO - 10.1016/j.pscychresns.2020.111058
M3 - Article
C2 - 32120304
AN - SCOPUS:85080041015
SN - 0925-4927
VL - 298
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
M1 - 111058
ER -