Tubulin messenger RNA: in situ hybridization reveals bilateral increases in hypoglossal and facial nuclei following nerve transection

R. Carl A. Pearson, Naomi Taylor, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

We have examined the levels of mRNA coding for tubulin in cranial nerve motor nuclei following axotomy using in situ hybridization histochemistry. Following division of their peripheral axons, the neurons in the facial and hypoglossal nuclei show increased levels of tubulin mRNA both ipsilateral and contralateral to the lesion. Tubulin in situ hybridization histochemistry provides a sensitive technique to monitor dynamics of neuronal regrowth or sprouting in the peripheral and possibly the central nervous system.

Original languageEnglish (US)
Pages (from-to)245-249
Number of pages5
JournalBrain research
Volume463
Issue number2
DOIs
StatePublished - Nov 1 1988

Keywords

  • Axon reaction
  • Axonal sprouting
  • In situ hybridization
  • Neuronal plasticity
  • Tubulin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Tubulin messenger RNA: in situ hybridization reveals bilateral increases in hypoglossal and facial nuclei following nerve transection'. Together they form a unique fingerprint.

Cite this