Tuberculosis in children with severe acute malnutrition

Bryan J. Vonasek, Kendra K. Radtke, Paula Vaz, W. Chris Buck, Chishala Chabala, Eric D. McCollum, Olivier Marcy, Elizabeth Fitzgerald, Alexander Kondwani, Anthony J. Garcia-Prats

Research output: Contribution to journalReview articlepeer-review


Introduction: With growing attention globally to the childhood tuberculosis epidemic after decades of neglect, and with the burden of severe acute malnutrition (SAM) remaining unacceptably high worldwide, the collision of these two diseases is an important focus for improving child health. Areas covered: This review describes the clinical and public health implications of the interplay between tuberculosis and SAM, particularly for children under the age of five, and identifies priority areas for improved programmatic implementation and future research. We reviewed the literature on PubMed and other evidence known to the authors published until August 2021 relevant to this topic. Expert opinion: To achieve the World Health Organization’s goal of eliminating deaths from childhood tuberculosis and to improve the abysmal outcomes for children with SAM, further research is needed to 1) better understand the epidemiologic connections between child tuberculosis and SAM, 2) improve case finding of tuberculosis in children with SAM, 3) assess unique treatment considerations for tuberculosis when children also have SAM, and 4) ensure tuberculosis and SAM are strongly addressed in decentralized, integrated models of providing primary healthcare to children.

Original languageEnglish (US)
Pages (from-to)273-284
Number of pages12
JournalExpert review of respiratory medicine
Issue number3
StatePublished - 2022


  • Childhood tuberculosis
  • severe acute malnutrition
  • tuberculosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health


Dive into the research topics of 'Tuberculosis in children with severe acute malnutrition'. Together they form a unique fingerprint.

Cite this