Tuberculosis and hypertension—a systematic review of the literature

Anneline Borchsenius Seegert, Frauke Rudolf, Christian Wejse, Dinesh Neupane

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Background Tuberculosis (TB) remains a major health problem in low- and middle-income countries, and in many of these countries, the burden of non-communicable diseases such as hypertension is rising. Knowledge about how these diseases influence each other is limited. Methods A systematic review of the literature was performed to evaluate the evidence for an association between hypertension and TB. Results Three retrospective cohort studies, three case–control studies, eight cross-sectional studies, 12 case series, and 20 case reports exploring the association between hypertension and TB were included in the review. One cohort study found a significantly higher prevalence of hypertension among TB patients compared to controls. Cross-sectional studies reported a prevalence of hypertension in TB patients ranging from 0.7% to 38.3%. No studies were designed to assess whether hypertension is a risk factor for developing active TB. Conclusions Overall, no evidence was found to support an association between TB and hypertension; however, the results of this review must be interpreted with caution due to the lack of properly designed studies.

Original languageEnglish (US)
Pages (from-to)54-61
Number of pages8
JournalInternational Journal of Infectious Diseases
StatePublished - Mar 1 2017
Externally publishedYes


  • Hypertension
  • Systematic review
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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