Tuberculosis and HIV infection: Epidemiology, pathogenesis, and clinical aspects

N. M.H. Graham, R. E. Chaisson

Research output: Contribution to journalReview articlepeer-review


Human immunodeficiency virus infection has profoundly affected the epidemiology, natural history, and clinical presentation of TB. It has also contributed in part to the recent epidemic of MDR-TB in the US and significantly reduced the sensitivity (but not the specificity) of the tuberculin skin test. Further research is needed to determine the optimal strategy for chemoprophylaxis in HIV-infected individuals, new methods of diagnosing TB infection and disease, and new drugs to control MDR-TB. Most importantly, however, further funding is necessary to improve compliance with therapy and chemoprophylaxis in order to regain control of this ancient scourge.

Original languageEnglish (US)
Pages (from-to)421-433
Number of pages13
JournalAnnals of allergy
Issue number5
StatePublished - 1993

ASJC Scopus subject areas

  • Immunology and Allergy


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