Tuberculosis and AIDS co-morbidity in children: Linkage of databases from espírito Santo State, Brazil

Angelica E. Miranda, Reynaldo Dietze, Ethel L. Maciel, Thiago N. Prado, Antonio L. Caus, Murilo M. Silva, Jonathan E. Golub

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed the prevalence of AIDS among children diagnosed with active tuberculosis (TB) in Espírito Santo State, Brazil, by linking TB and AIDS surveillance databases using Reclink software and SPSS. Among 411 pediatric TB cases from 2000 to 2006, 27 (7%) were co-infected with AIDS. Most children were unable to provide a sputum specimen; co-infected patients were more likely to be smear negative for acid-fast bacilli (83% vs 46%; p = 0.07) and culture positive for Mycobacterium tuberculosis (44% vs 19%; p < 0.001). In all, 57% of co-infected patients did not react to tuberculin skin test compared with 17% of TB patients (p < 0.001). This report emphasizes the significance of AIDS in pediatric TB cases and highlights the importance of evaluating surveillance databases for gaining a better understanding of the burden of co-infection.

Original languageEnglish (US)
Article numberfmq087
Pages (from-to)296-298
Number of pages3
JournalJournal of tropical pediatrics
Volume57
Issue number4
DOIs
StatePublished - Aug 2011

Keywords

  • AIDS
  • Children
  • Co-infection
  • Tuberculosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

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