TSLP polymorphisms are associated with asthma in a sex-specific fashion

G. M. Hunninghake, M. E. Soto-Quirós, L. Avila, H. P. Kim, J. Lasky-Su, N. Rafaels, I. Ruczinski, T. H. Beaty, R. A. Mathias, K. C. Barnes, J. B. Wilk, G. T. Oconnor, W. James Gauderman, H. Vora, J. W. Baurley, F. Gilliland, C. Liang, J. S. Sylvia, B. J. Klanderman, S. S. SharmaB. E. Himes, C. J. Bossley, E. Israel, B. A. Raby, A. Bush, A. M. Choi, S. T. Weiss, J. C. Celedón

Research output: Contribution to journalArticle

Abstract

Background: Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion. Methods: We conducted regular and sex-stratified analyses of association between SNPs in TSLP and asthma in families of children with asthma in Costa Rica. Significant findings were replicated in whites and African-American participants in the Childhood Asthma Management Program, in African-Americans in the Genomic Research on Asthma in the African Diaspora study, in whites and Hispanics in the Childrens Health Study, and in whites in the Framingham Heart Study (FHS). Main Results: Two SNPs in TSLP (rs1837253 and rs2289276) were significantly associated with a reduced risk of asthma in combined analyses of all cohorts (P values of 2×105 and 1×105, respectively). In a sex-stratified analysis, the T allele of rs1837253 was significantly associated with a reduced risk of asthma in males only (P=3×106). Alternately, the T allele of rs2289276 was significantly associated with a reduced risk of asthma in females only (P=2×104). Findings for rs2289276 were consistent in all cohorts except the FHS. Conclusions: TSLP variants are associated with asthma in a sex-specific fashion.

Original languageEnglish (US)
Pages (from-to)1566-1575
Number of pages10
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume65
Issue number12
DOIs
StatePublished - Dec 2010

Keywords

  • Asthma
  • Genetic association
  • Sex-specific
  • TSLP
  • Thymic stromal lymphopoietin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'TSLP polymorphisms are associated with asthma in a sex-specific fashion'. Together they form a unique fingerprint.

  • Cite this

    Hunninghake, G. M., Soto-Quirós, M. E., Avila, L., Kim, H. P., Lasky-Su, J., Rafaels, N., Ruczinski, I., Beaty, T. H., Mathias, R. A., Barnes, K. C., Wilk, J. B., Oconnor, G. T., James Gauderman, W., Vora, H., Baurley, J. W., Gilliland, F., Liang, C., Sylvia, J. S., Klanderman, B. J., ... Celedón, J. C. (2010). TSLP polymorphisms are associated with asthma in a sex-specific fashion. Allergy: European Journal of Allergy and Clinical Immunology, 65(12), 1566-1575. https://doi.org/10.1111/j.1398-9995.2010.02415.x