TSLP polymorphisms are associated with asthma in a sex-specific fashion

G. M. Hunninghake; M. E. Soto-Quirós; L. Avila; H. P. Kim; J. Lasky-Su; N. Rafaels; I. Ruczinski; T. H. Beaty; R. A. Mathias; K. C. Barnes; J. B. Wilk; G. T. Oconnor; W. James Gauderman; H. Vora; J. W. Baurley; F. Gilliland; C. Liang; J. S. Sylvia; B. J. Klanderman; S. S. Sharma; B. E. Himes; C. J. Bossley; E. Israel; B. A. Raby; A. Bush; A. M. Choi; S. T. Weiss; J. C. Celedón

doi:10.1111/j.1398-9995.2010.02415.x

TSLP polymorphisms are associated with asthma in a sex-specific fashion

G. M. Hunninghake, M. E. Soto-Quirós, L. Avila, H. P. Kim, J. Lasky-Su, N. Rafaels, I. Ruczinski, T. H. Beaty, R. A. Mathias, K. C. Barnes, J. B. Wilk, G. T. Oconnor, W. James Gauderman, H. Vora, J. W. Baurley, F. Gilliland, C. Liang, J. S. Sylvia, B. J. Klanderman, S. S. SharmaB. E. Himes, C. J. Bossley, E. Israel, B. A. Raby, A. Bush, A. M. Choi, S. T. Weiss, J. C. Celedón

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion. Methods: We conducted regular and sex-stratified analyses of association between SNPs in TSLP and asthma in families of children with asthma in Costa Rica. Significant findings were replicated in whites and African-American participants in the Childhood Asthma Management Program, in African-Americans in the Genomic Research on Asthma in the African Diaspora study, in whites and Hispanics in the Childrens Health Study, and in whites in the Framingham Heart Study (FHS). Main Results: Two SNPs in TSLP (rs1837253 and rs2289276) were significantly associated with a reduced risk of asthma in combined analyses of all cohorts (P values of 2×10⁵ and 1×10⁵, respectively). In a sex-stratified analysis, the T allele of rs1837253 was significantly associated with a reduced risk of asthma in males only (P=3×10⁶). Alternately, the T allele of rs2289276 was significantly associated with a reduced risk of asthma in females only (P=2×10⁴). Findings for rs2289276 were consistent in all cohorts except the FHS. Conclusions: TSLP variants are associated with asthma in a sex-specific fashion.

Original language	English (US)
Pages (from-to)	1566-1575
Number of pages	10
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	65
Issue number	12
DOIs	https://doi.org/10.1111/j.1398-9995.2010.02415.x
State	Published - Dec 2010

Keywords

Asthma
Genetic association
Sex-specific
TSLP
Thymic stromal lymphopoietin

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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Hunninghake, G. M., Soto-Quirós, M. E., Avila, L., Kim, H. P., Lasky-Su, J., Rafaels, N., Ruczinski, I., Beaty, T. H., Mathias, R. A., Barnes, K. C., Wilk, J. B., Oconnor, G. T., James Gauderman, W., Vora, H., Baurley, J. W., Gilliland, F., Liang, C., Sylvia, J. S., Klanderman, B. J., ... Celedón, J. C. (2010). TSLP polymorphisms are associated with asthma in a sex-specific fashion. Allergy: European Journal of Allergy and Clinical Immunology, 65(12), 1566-1575. https://doi.org/10.1111/j.1398-9995.2010.02415.x

Hunninghake, GM, Soto-Quirós, ME, Avila, L, Kim, HP, Lasky-Su, J, Rafaels, N, Ruczinski, I , Beaty, TH, Mathias, RA, Barnes, KC, Wilk, JB, Oconnor, GT, James Gauderman, W, Vora, H, Baurley, JW, Gilliland, F, Liang, C, Sylvia, JS, Klanderman, BJ, Sharma, SS, Himes, BE, Bossley, CJ, Israel, E, Raby, BA, Bush, A, Choi, AM, Weiss, ST & Celedón, JC 2010, 'TSLP polymorphisms are associated with asthma in a sex-specific fashion', Allergy: European Journal of Allergy and Clinical Immunology, vol. 65, no. 12, pp. 1566-1575. https://doi.org/10.1111/j.1398-9995.2010.02415.x

@article{9e33cc6b2f7842fe8d3a004ce31e0ccd,

title = "TSLP polymorphisms are associated with asthma in a sex-specific fashion",

abstract = "Background: Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion. Methods: We conducted regular and sex-stratified analyses of association between SNPs in TSLP and asthma in families of children with asthma in Costa Rica. Significant findings were replicated in whites and African-American participants in the Childhood Asthma Management Program, in African-Americans in the Genomic Research on Asthma in the African Diaspora study, in whites and Hispanics in the Childrens Health Study, and in whites in the Framingham Heart Study (FHS). Main Results: Two SNPs in TSLP (rs1837253 and rs2289276) were significantly associated with a reduced risk of asthma in combined analyses of all cohorts (P values of 2×105 and 1×105, respectively). In a sex-stratified analysis, the T allele of rs1837253 was significantly associated with a reduced risk of asthma in males only (P=3×106). Alternately, the T allele of rs2289276 was significantly associated with a reduced risk of asthma in females only (P=2×104). Findings for rs2289276 were consistent in all cohorts except the FHS. Conclusions: TSLP variants are associated with asthma in a sex-specific fashion.",

keywords = "Asthma, Genetic association, Sex-specific, TSLP, Thymic stromal lymphopoietin",

author = "Hunninghake, {G. M.} and Soto-Quir{\'o}s, {M. E.} and L. Avila and Kim, {H. P.} and J. Lasky-Su and N. Rafaels and I. Ruczinski and Beaty, {T. H.} and Mathias, {R. A.} and Barnes, {K. C.} and Wilk, {J. B.} and Oconnor, {G. T.} and {James Gauderman}, W. and H. Vora and Baurley, {J. W.} and F. Gilliland and C. Liang and Sylvia, {J. S.} and Klanderman, {B. J.} and Sharma, {S. S.} and Himes, {B. E.} and Bossley, {C. J.} and E. Israel and Raby, {B. A.} and A. Bush and Choi, {A. M.} and Weiss, {S. T.} and Celed{\'o}n, {J. C.}",

year = "2010",

month = dec,

doi = "10.1111/j.1398-9995.2010.02415.x",

language = "English (US)",

volume = "65",

pages = "1566--1575",

journal = "Allergy: European Journal of Allergy and Clinical Immunology",

issn = "0105-4538",

publisher = "Wiley-Blackwell",

number = "12",

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TY - JOUR

T1 - TSLP polymorphisms are associated with asthma in a sex-specific fashion

AU - Hunninghake, G. M.

AU - Soto-Quirós, M. E.

AU - Avila, L.

AU - Kim, H. P.

AU - Lasky-Su, J.

AU - Rafaels, N.

AU - Ruczinski, I.

AU - Beaty, T. H.

AU - Mathias, R. A.

AU - Barnes, K. C.

AU - Wilk, J. B.

AU - Oconnor, G. T.

AU - James Gauderman, W.

AU - Vora, H.

AU - Baurley, J. W.

AU - Gilliland, F.

AU - Liang, C.

AU - Sylvia, J. S.

AU - Klanderman, B. J.

AU - Sharma, S. S.

AU - Himes, B. E.

AU - Bossley, C. J.

AU - Israel, E.

AU - Raby, B. A.

AU - Bush, A.

AU - Choi, A. M.

AU - Weiss, S. T.

AU - Celedón, J. C.

PY - 2010/12

Y1 - 2010/12

N2 - Background: Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion. Methods: We conducted regular and sex-stratified analyses of association between SNPs in TSLP and asthma in families of children with asthma in Costa Rica. Significant findings were replicated in whites and African-American participants in the Childhood Asthma Management Program, in African-Americans in the Genomic Research on Asthma in the African Diaspora study, in whites and Hispanics in the Childrens Health Study, and in whites in the Framingham Heart Study (FHS). Main Results: Two SNPs in TSLP (rs1837253 and rs2289276) were significantly associated with a reduced risk of asthma in combined analyses of all cohorts (P values of 2×105 and 1×105, respectively). In a sex-stratified analysis, the T allele of rs1837253 was significantly associated with a reduced risk of asthma in males only (P=3×106). Alternately, the T allele of rs2289276 was significantly associated with a reduced risk of asthma in females only (P=2×104). Findings for rs2289276 were consistent in all cohorts except the FHS. Conclusions: TSLP variants are associated with asthma in a sex-specific fashion.

AB - Background: Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion. Methods: We conducted regular and sex-stratified analyses of association between SNPs in TSLP and asthma in families of children with asthma in Costa Rica. Significant findings were replicated in whites and African-American participants in the Childhood Asthma Management Program, in African-Americans in the Genomic Research on Asthma in the African Diaspora study, in whites and Hispanics in the Childrens Health Study, and in whites in the Framingham Heart Study (FHS). Main Results: Two SNPs in TSLP (rs1837253 and rs2289276) were significantly associated with a reduced risk of asthma in combined analyses of all cohorts (P values of 2×105 and 1×105, respectively). In a sex-stratified analysis, the T allele of rs1837253 was significantly associated with a reduced risk of asthma in males only (P=3×106). Alternately, the T allele of rs2289276 was significantly associated with a reduced risk of asthma in females only (P=2×104). Findings for rs2289276 were consistent in all cohorts except the FHS. Conclusions: TSLP variants are associated with asthma in a sex-specific fashion.

KW - Asthma

KW - Genetic association

KW - Sex-specific

KW - TSLP

KW - Thymic stromal lymphopoietin

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AN - SCOPUS:78349283420

SN - 0105-4538

VL - 65

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JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

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ER -

TSLP polymorphisms are associated with asthma in a sex-specific fashion

Abstract

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