TY - JOUR
T1 - Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders
T2 - A Multicenter Association Study
AU - Souery, Daniel
AU - Van Gestel, Sophie
AU - Massat, Isabelle
AU - Blairy, Sylvie
AU - Adolfsson, Rolf
AU - Blackwood, Douglas
AU - Del-Favero, Jurgen
AU - Dikeos, Dimitris
AU - Jakovljevic, Miro
AU - Kaneva, Radka
AU - Lattuada, Enrico
AU - Lerer, Bernard
AU - Lilli, Roberta
AU - Milanova, Vihbra
AU - Muir, Walter
AU - Nöthen, Markus
AU - Oruc, Lilijana
AU - Papadimitriou, George
AU - Propping, Peter
AU - Schulze, Thomas
AU - Serretti, Alessandro
AU - Shapira, Baruch
AU - Smeraldi, Enrico
AU - Stefanis, Costas
AU - Thomson, Marian
AU - Van Broeckhoven, Christine
AU - Mendlewicz, Julien
PY - 2001/3/1
Y1 - 2001/3/1
N2 - Background: Being the rate-limiting enzyme in the biosynthesis of serotonin, the tryptophan hydroxylase gene (TPH) has been considered a possible candidate gene in bipolar and unipolar affective disorders (BPAD and UPAD). Several studies have investigated the possible role of TPH polymorphisms in affective disorders and suicidal behavior. Methods: The TPH A218C polymorphism has been investigated in 927 patients (527 BPAD and 400 UPAD) and their matched healthy control subjects collected within the European Collaborative Project on Affective Disorders. Results: No difference of genotype distribution or allele distribution was found in BPAD or UPAD. No statistically significant difference was observed for allele frequency and genotypes counts. In a genotype per genotype analysis in UPAD patients with a personal history of suicide attempt, the frequency of the C-C genotype (homozygosity for the short allele) was lower in UPAD patients (24%) than in control subjects (43%) (χ2 = 4.67, p = .03). There was no difference in allele or genotype frequency between patients presenting violent suicidal behavior (n = 48) and their matched control subjects. Conclusions: We failed to detect an association between the A218C polymorphism of the TPH gene and BPAD and UPAD in a large European sample. Homozygosity for the short allele is significantly less frequent in a subgroup of UPAD patients with a history of suicide attempt than in control subjects.
AB - Background: Being the rate-limiting enzyme in the biosynthesis of serotonin, the tryptophan hydroxylase gene (TPH) has been considered a possible candidate gene in bipolar and unipolar affective disorders (BPAD and UPAD). Several studies have investigated the possible role of TPH polymorphisms in affective disorders and suicidal behavior. Methods: The TPH A218C polymorphism has been investigated in 927 patients (527 BPAD and 400 UPAD) and their matched healthy control subjects collected within the European Collaborative Project on Affective Disorders. Results: No difference of genotype distribution or allele distribution was found in BPAD or UPAD. No statistically significant difference was observed for allele frequency and genotypes counts. In a genotype per genotype analysis in UPAD patients with a personal history of suicide attempt, the frequency of the C-C genotype (homozygosity for the short allele) was lower in UPAD patients (24%) than in control subjects (43%) (χ2 = 4.67, p = .03). There was no difference in allele or genotype frequency between patients presenting violent suicidal behavior (n = 48) and their matched control subjects. Conclusions: We failed to detect an association between the A218C polymorphism of the TPH gene and BPAD and UPAD in a large European sample. Homozygosity for the short allele is significantly less frequent in a subgroup of UPAD patients with a history of suicide attempt than in control subjects.
KW - Association study
KW - Bipolar affective disorders
KW - Linkage disequilibrium
KW - Suicide
KW - Tryptophan hydroxylase polymorphism
UR - http://www.scopus.com/inward/record.url?scp=0035281091&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035281091&partnerID=8YFLogxK
U2 - 10.1016/S0006-3223(00)01043-X
DO - 10.1016/S0006-3223(00)01043-X
M3 - Article
C2 - 11274651
AN - SCOPUS:0035281091
SN - 0006-3223
VL - 49
SP - 405
EP - 409
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 5
ER -