Trypanosoma cruzi meningoencephalitis in HIV-infected patients

Nanci Silva; Laura O'Bryan; Eduardo Medeiros; H. Holand; J. Suleiman; João Silva De Mendonca; Nicholas Patronas; Steven G. Reed; Harvey G. Klein; Henry Masur; Roberto Badaro

Trypanosoma cruzi meningoencephalitis in HIV-infected patients

Nanci Silva, Laura O'Bryan, Eduardo Medeiros, H. Holand, J. Suleiman, João Silva De Mendonca, Nicholas Patronas, Steven G. Reed, Harvey G. Klein, Henry Masur, Roberto Badaro

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Five cases of Trypanosoma cruzi meningoencephalitis in HIV-infected patients are reported. All patients presented with mass lesions on head computed tomographic scan, trypanosomes in the cerebrospinal fluid and failure to respond to antitoxoplasmosis therapy. Benznidazole therapy was associated with clinical improvement in 1 patient. Another 4 patients had T cruzi identified in a peripheral smear. T cruzi needs to be considered in the differential diagnosis of HIV-infected patients with central nervous system mass lesions if they have a history of appropriate exposure.

Original language	English (US)
Pages (from-to)	342-349
Number of pages	8
Journal	Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume	20
Issue number	4
State	Published - Apr 1 1999
Externally published	Yes

Keywords

AIDS
Chagas' disease
HIV
Meningoencephalitis
Toxoplasmosis

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Virology

Cite this

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title = "Trypanosoma cruzi meningoencephalitis in HIV-infected patients",

abstract = "Five cases of Trypanosoma cruzi meningoencephalitis in HIV-infected patients are reported. All patients presented with mass lesions on head computed tomographic scan, trypanosomes in the cerebrospinal fluid and failure to respond to antitoxoplasmosis therapy. Benznidazole therapy was associated with clinical improvement in 1 patient. Another 4 patients had T cruzi identified in a peripheral smear. T cruzi needs to be considered in the differential diagnosis of HIV-infected patients with central nervous system mass lesions if they have a history of appropriate exposure.",

keywords = "AIDS, Chagas' disease, HIV, Meningoencephalitis, Toxoplasmosis",

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T1 - Trypanosoma cruzi meningoencephalitis in HIV-infected patients

AU - Silva, Nanci

AU - O'Bryan, Laura

AU - Medeiros, Eduardo

AU - Holand, H.

AU - Suleiman, J.

AU - De Mendonca, João Silva

AU - Patronas, Nicholas

AU - Reed, Steven G.

AU - Klein, Harvey G.

AU - Masur, Henry

AU - Badaro, Roberto

PY - 1999/4/1

Y1 - 1999/4/1

N2 - Five cases of Trypanosoma cruzi meningoencephalitis in HIV-infected patients are reported. All patients presented with mass lesions on head computed tomographic scan, trypanosomes in the cerebrospinal fluid and failure to respond to antitoxoplasmosis therapy. Benznidazole therapy was associated with clinical improvement in 1 patient. Another 4 patients had T cruzi identified in a peripheral smear. T cruzi needs to be considered in the differential diagnosis of HIV-infected patients with central nervous system mass lesions if they have a history of appropriate exposure.

AB - Five cases of Trypanosoma cruzi meningoencephalitis in HIV-infected patients are reported. All patients presented with mass lesions on head computed tomographic scan, trypanosomes in the cerebrospinal fluid and failure to respond to antitoxoplasmosis therapy. Benznidazole therapy was associated with clinical improvement in 1 patient. Another 4 patients had T cruzi identified in a peripheral smear. T cruzi needs to be considered in the differential diagnosis of HIV-infected patients with central nervous system mass lesions if they have a history of appropriate exposure.

KW - AIDS

KW - Chagas' disease

KW - HIV

KW - Meningoencephalitis

KW - Toxoplasmosis

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JF - Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

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Trypanosoma cruzi meningoencephalitis in HIV-infected patients

Abstract

Keywords

ASJC Scopus subject areas

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