@article{3ede5bac827a40f5b3d82c0a6c1fdbaf,
title = "Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes",
abstract = "Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by the progressive loss of dopaminergic (DA) neurons. Most PD cases are sporadic; however, rare familial forms have been identified. Autosomal recessive PD (ARPD) results from mutations in Parkin, PINK1, DJ-1, and ATP13A2, while rare, atypical juvenile ARPD result from mutations in FBXO7, DNAJC6, SYNJ1, and PLA2G6. Studying these genes and their function has revealed mitochondrial quality control, protein degradation processes, and oxidative stress responses as common pathways underlying PD pathogenesis. Understanding how aberrancy in these common processes leads to neurodegeneration has provided the field with numerous targets that may be therapeutically relevant to the development of disease-modifying treatments.",
keywords = "Autosomal recessive Parkinson's disease, Mitochondria, Oxidative stress, PINK1, Parkin, Protein degradation",
author = "Laura Scott and Dawson, {Valina L.} and Dawson, {Ted M.}",
note = "Funding Information: Supported by NIH/NINDS grant P50 NS38377 and the JPB Foundation . T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases. X.B., V.L.D. and T.M.D. acknowledge the joint participation by the Adrienne Helis Malvin Medical Research Foundation through its direct engagement in the continuous active conduct of medical research in conjunction with the Johns Hopkins Hospital and the Johns Hopkins University School of Medicine and the Foundation's Parkinson's Disease Program M-2014. Funding Information: Supported by NIH/NINDS grant P50 NS38377 and the JPB Foundation. T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases. X.B., V.L.D. and T.M.D. acknowledge the joint participation by the Adrienne Helis Malvin Medical Research Foundation through its direct engagement in the continuous active conduct of medical research in conjunction with the Johns Hopkins Hospital and the Johns Hopkins University School of Medicine and the Foundation's Parkinson's Disease Program M-2014. Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",
year = "2017",
month = dec,
doi = "10.1016/j.expneurol.2017.04.008",
language = "English (US)",
volume = "298",
pages = "191--201",
journal = "Neurodegeneration",
issn = "0014-4886",
publisher = "Academic Press Inc.",
}