TRPV channels as thermosensory receptors in epithelial cells

Hyosang Lee, Michael J. Caterina

Research output: Contribution to journalReview articlepeer-review

116 Scopus citations


Temperature-sensitive transient receptor potential vanilloid (TRPV) ion channels are critical contributors to normal pain and temperature sensation and therefore represent attractive targets for pain therapy. When these channels were first discovered, most attention was focused on their potential contributions to direct thermal activation of peripheral sensory neurons. However, recent anatomical, physiological, and behavioral studies have provided evidence that TRPV channels expressed in skin epithelial cells may also contribute to thermosensation in vitro and in vivo. Here, we review these studies and speculate on possible communication mechanisms from cutaneous epithelial cells to sensory neurons.

Original languageEnglish (US)
Pages (from-to)160-167
Number of pages8
JournalPflugers Archiv European Journal of Physiology
Issue number1
StatePublished - Oct 1 2005


  • Epithelia
  • Ion channel
  • Keratinocytes
  • Pain
  • Skin
  • TRPV
  • Temperature
  • Thermosensation

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)


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