TRPA1: A potential target for anti-tussive therapy

Thomas E. Taylor-Clark, Christina Nassenstein, M. Allen McAlexander, Bradley J. Undem

Research output: Contribution to journalArticle

Abstract

Cough occurs as a result of the activation of specific airway sensory nerves. The mechanisms by which tussive stimuli activate these sensory nerves are starting to be understood and suggest that TRPA1 channels are heavily involved. TRPA1 channels are nociceptor-specific ion channels that are gated by a wide range of exogenous irritants and endogenously-produced inflammatory mediators, suggesting that the blockade of TRPA1 represents a novel therapy for the treatment of cough in humans.

Original languageEnglish (US)
Pages (from-to)71-74
Number of pages4
JournalPulmonary Pharmacology and Therapeutics
Volume22
Issue number2
DOIs
StatePublished - Apr 1 2009

Keywords

  • Airway sensory nerve
  • Asthma
  • C-fiber
  • COPD
  • Cough
  • Electrophilic
  • Irritant
  • Nociceptor
  • Oxidative stress
  • Reactive
  • TRPA1
  • TRPV1

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Biochemistry, medical
  • Pharmacology (medical)

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