Trp channels and itch

Shuohao Sun, Xinzhong Dong

Research output: Contribution to journalReview article

Abstract

Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly understood until recently. The goal of the present review is to summarize our current understanding of the mechanisms of acute as well as chronic itch and classifications of the primary itch populations in relationship to transient receptor potential (Trp) channels, which play pivotal roles in multiple somatosensations. The convergent involvement of Trp channels in diverse itch signaling pathways suggests that Trp channels may serve as promising targets for chronic itch treatments.

Original languageEnglish (US)
Pages (from-to)293-307
Number of pages15
JournalSeminars in Immunopathology
Volume38
Issue number3
DOIs
StatePublished - May 1 2016

Keywords

  • DRG neurons
  • GPCR
  • Itch
  • Skin
  • Trp channel

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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