TRP channel cannabinoid receptors in skin sensation, homeostasis, and inflammation

Research output: Contribution to journalReview articlepeer-review

Abstract

In the skin, cannabinoid lipids, whether of endogenous or exogenous origin, are capable of regulating numerous sensory, homeostatic, and inflammatory events. Although many of these effects are mediated by metabotropic cannabinoid receptors, a growing body of evidence has revealed that multiple members of the transient receptor potential (TRP) ion channel family can act as "ionotropic cannabinoid receptors". Furthermore, many of these same TRP channels are intimately involved in cutaneous processes that include the initiation of pain, temperature, and itch perception, the maintenance of epidermal homeostasis, the regulation of hair follicles and sebaceous glands, and the modulation of dermatitis. Ionotropic cannabinoid receptors therefore represent potentially attractive targets for the therapeutic use of cannabinoids to treat sensory and dermatological diseases. Furthermore, the interactions between neurons and other cell types that are mediated by cutaneous ionotropic cannabinoid receptors are likely to be recapitulated during physiological and pathophysiological processes in the central nervous system and elsewhere, making the skin an ideal setting in which to dissect general complexities of cannabinoid signaling. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)1107-1116
Number of pages10
JournalACS Chemical Neuroscience
Volume5
Issue number11
DOIs
StatePublished - Nov 19 2014

Keywords

  • Cannabinoids
  • Dermatitis
  • Ion channel
  • Nociception
  • Pruritis
  • Transient receptor potential

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Cognitive Neuroscience
  • Cell Biology

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