Trophic regulation of acetylcholine sensitivity of muscle: Effect of electrical stimulation

Daniel B. Drachman, Fredrica Witzke

Research output: Contribution to journalArticlepeer-review

Abstract

Denervation of skeletal muscle results in a spread of acetylcholine sensitivity over the entire surface membrane. Electrical stimulation, programmed to mimic the normal activity pattern, was applied continuously to the denervated rat diaphragm in vivo. After 4 days, the acetylcholine sensitivity was far less in the stimulated diaphragms than in denervated controls. Muscle activity may account for "neurotrophic" regulation of the acetylcholine sensitivity.

Original languageEnglish (US)
Pages (from-to)514-516
Number of pages3
JournalScience
Volume176
Issue number4034
DOIs
StatePublished - Jan 1 1972

ASJC Scopus subject areas

  • General

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