Abstract
Denervation of skeletal muscle results in a spread of acetylcholine sensitivity over the entire surface membrane. Electrical stimulation, programmed to mimic the normal activity pattern, was applied continuously to the denervated rat diaphragm in vivo. After 4 days, the acetylcholine sensitivity was far less in the stimulated diaphragms than in denervated controls. Muscle activity may account for "neurotrophic" regulation of the acetylcholine sensitivity.
Original language | English (US) |
---|---|
Pages (from-to) | 514-516 |
Number of pages | 3 |
Journal | Science |
Volume | 176 |
Issue number | 4034 |
DOIs | |
State | Published - Jan 1 1972 |
ASJC Scopus subject areas
- General