Triple Hit Lymphoma: Rare Cases with Less Dire Than Usual Prognosis

Michael E. Kallen, Serge Alexanian, Jonathan Said, Fabiola Quintero-Rivera

Research output: Contribution to journalArticlepeer-review

Abstract

Triple hit lymphomas are a subset of so-called double hit non-Hodgkin lymphomas exhibiting simultaneous gene translocations/disruption of MYC, BCL2, and BCL6; however, their overlapping morphologic features and complex genetic rearrangements can render classification and prognostication vexing. Clinically triple hit lymphomas are thought to demonstrate aggressive behavior, similar to or worse than that of double hit lymphomas. Only rare reports of long term survivors exist and raise the possibility that unidentified morphologic, immunologic, or cytogenetic differences may impart a less adverse prognosis than current literature and opinion may suggest. Here we report 3 such cases with less aggressive behavior. Cases such as these may prove useful in comparing outcomes, and underlying mechanisms of tumor progression, in aggressive non-Hodgkin lymphomas.

Original languageEnglish (US)
Pages (from-to)709-714
Number of pages6
JournalInternational Journal of Surgical Pathology
Volume24
Issue number8
DOIs
StatePublished - Dec 1 2016
Externally publishedYes

Keywords

  • aggressive non-Hodgkin lymphoma
  • BCL2
  • BCL6
  • MYC
  • triple hit lymphoma

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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