Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro

Gary H. Posner, Poonsakdi Ploypradith, Whitney Hapangama, Dasong Wang, Jared N. Cumming, Patrick Dolan, Thomas W. Kensler, Donna Klinedinst, Theresa A. Shapiro, Qun Yi Zheng, Christopher K. Murray, Lynn G. Pilkington, Lalith R. Jayasinghe, Jeff F. Bray, Randy Daughenbaugh

Research output: Contribution to journalArticlepeer-review

Abstract

A series of tetracyclic and tricyclic trioxane dimers has been prepared with ether and ester tethers of varying length and flexibility. Several of these trioxane dimers have been found to have potent and potentially therapeutically valuable antimalarial, antiproliferative, and antitumor activities in vitro.

Original languageEnglish (US)
Pages (from-to)1257-1265
Number of pages9
JournalBioorganic and Medicinal Chemistry
Volume5
Issue number7
DOIs
StatePublished - Jul 1997
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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