Trimethoprim-sulfamethoxazole compared with ampicillin in the treatment of acute otitis media

Paul S. Lietman, Paul A. Shurin, Stephen I. Pelton, Allan Donner, Joan Finkelstein, Jerome O. Klein

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

We treated 132 children with acute otitis media in a randomized trial comparing trimethoprim-sulfamethoxazole and ampicillin. The antibacterial efficacy of the drugs was assessed primarly from the results of cultures of middle ear aspirates obtained during or after the course of therapy; persistent, recurrent, and new infections of the middle ear were documented in both groups of patients but did not differ significantly. Both drug regimens were well accepted by the patients and were not associated with serious side effects or toxicity. TMP-SMZ is an effective alternate to AMP or to other accepted regimens for initial treatment of acute otitis media.

Original languageEnglish (US)
Pages (from-to)1081-1087
Number of pages7
JournalThe Journal of pediatrics
Volume96
Issue number6
DOIs
StatePublished - Jun 1980
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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