@article{e433e6c9ab3140e9b88adfeb825a812b,
title = "Trimethoprim-sulfamethoxazole compared with ampicillin in the treatment of acute otitis media",
abstract = "We treated 132 children with acute otitis media in a randomized trial comparing trimethoprim-sulfamethoxazole and ampicillin. The antibacterial efficacy of the drugs was assessed primarly from the results of cultures of middle ear aspirates obtained during or after the course of therapy; persistent, recurrent, and new infections of the middle ear were documented in both groups of patients but did not differ significantly. Both drug regimens were well accepted by the patients and were not associated with serious side effects or toxicity. TMP-SMZ is an effective alternate to AMP or to other accepted regimens for initial treatment of acute otitis media.",
author = "Lietman, {Paul S.} and Shurin, {Paul A.} and Pelton, {Stephen I.} and Allan Donner and Joan Finkelstein and Klein, {Jerome O.}",
note = "Funding Information: From the Channing Laboratory and the Departments of Pediatrics and Preventive and Social Medicine, Harvard Medical School, the Departments of Pediatrics and Medical Microbiology, Boston City Hospital, and the Department of Pediatrics, Boston University School of Medicine. Supported by a grant (HD-03693) from the National Institute of ChiM Health and Human Development and by grants from Burroughs Wellcome Company and Hoffmann-LaRoche, Inc. Presented in part to the 15th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, D.C., September, 1975. *Reprint address: Department of Pediatrics, Cleveland Metropolitan General Hospital, 3395 Scranton Road, Cleveland, OH 44109.",
year = "1980",
month = jun,
doi = "10.1016/S0022-3476(80)80649-4",
language = "English (US)",
volume = "96",
pages = "1081--1087",
journal = "The Journal of pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "6",
}