Abstract
We compared the effectiveness of rifampin-trimethoprim in fixed combination (3.75:1) to rifampin alone in the eradication of Haemophilus influenzae type b carriage among contacts of patients with invasive infection caused by this organism. The study population was composed of 127 index patients and 620 contacts. Twenty-six percent of contacts were colonized. Rifampin-trimethoprim eradicated carriage in 77.6% of contacts (71.1% in contacts <5 years, 84.2% in contacts ≥5 years) whereas rifampin eradicated carriage in 69.9% of contacts (56.4% in contacts <5 years, 81.8% in contacts ≥5 years). A single isolate resistant to rifampin and rifampin-trimethoprim was encountered. The eradication rate achieved with this regimen of rifampin-trimethoprim was too low to recommend its routine use. However, a higher dose or longer course might merit clinical trial.
Original language | English (US) |
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Pages (from-to) | 658-662 |
Number of pages | 5 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 24 |
Issue number | 5 |
DOIs | |
State | Published - 1983 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases