Trimethoprim and rifampin in combination for chemoprophylaxis of household contacts of patients with invasive infections due to Haemophilus influenzae type b

R. S. Daum, M. P. Glode, D. Ambrosino, N. Halsey, D. A. Goldmann, F. J. Mather, R. Russell, J. Kamon, M. Murray, J. D. Band

Research output: Contribution to journalArticlepeer-review

Abstract

We compared the effectiveness of rifampin-trimethoprim in fixed combination (3.75:1) to rifampin alone in the eradication of Haemophilus influenzae type b carriage among contacts of patients with invasive infection caused by this organism. The study population was composed of 127 index patients and 620 contacts. Twenty-six percent of contacts were colonized. Rifampin-trimethoprim eradicated carriage in 77.6% of contacts (71.1% in contacts <5 years, 84.2% in contacts ≥5 years) whereas rifampin eradicated carriage in 69.9% of contacts (56.4% in contacts <5 years, 81.8% in contacts ≥5 years). A single isolate resistant to rifampin and rifampin-trimethoprim was encountered. The eradication rate achieved with this regimen of rifampin-trimethoprim was too low to recommend its routine use. However, a higher dose or longer course might merit clinical trial.

Original languageEnglish (US)
Pages (from-to)658-662
Number of pages5
JournalAntimicrobial agents and chemotherapy
Volume24
Issue number5
DOIs
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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