Trihexyphenidyl in posthemorrhagic dystonia: Motor and language effects

Research output: Contribution to journalArticle

Abstract

Trihexyphenidyl has been found to be an effective treatment for dystonic movement disorders, improving gross motor function in patients with axial and torsional dystonia, tremors, and myoclonus. In this report, improvements in fine motor control, language, and oral motor skills are described with trihexyphenidyl in an 8-year-old female who developed dystonia after spontaneous bilateral putamenal hemorrhages. No adverse side effects occurred. The mechanism of action of trihexyphenidyl is believed to be in the basal ganglia where it inhibits muscarinic cholinergic receptors and increases the turnover of dopamine.

Original languageEnglish (US)
Pages (from-to)219-222
Number of pages4
JournalPediatric Neurology
Volume20
Issue number3
DOIs
StatePublished - Mar 1999

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Trihexyphenidyl
Dystonia
Language
Dystonic Disorders
Motor Skills
Movement Disorders
Cholinergic Receptors
Tremor
Muscarinic Receptors
Basal Ganglia
Dopamine
Hemorrhage
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

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