Trihexyphenidyl in posthemorrhagic dystonia: Motor and language effects

Frank S. Pidcock; Alexander H. Hoon; Michael V. Johnston

doi:10.1016/S0887-8994(98)00140-4

Trihexyphenidyl in posthemorrhagic dystonia: Motor and language effects

Frank S. Pidcock, Alexander H. Hoon, Michael V. Johnston

Kennedy Krieger Institute

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Trihexyphenidyl has been found to be an effective treatment for dystonic movement disorders, improving gross motor function in patients with axial and torsional dystonia, tremors, and myoclonus. In this report, improvements in fine motor control, language, and oral motor skills are described with trihexyphenidyl in an 8-year-old female who developed dystonia after spontaneous bilateral putamenal hemorrhages. No adverse side effects occurred. The mechanism of action of trihexyphenidyl is believed to be in the basal ganglia where it inhibits muscarinic cholinergic receptors and increases the turnover of dopamine.

Original language	English (US)
Pages (from-to)	219-222
Number of pages	4
Journal	Pediatric Neurology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/S0887-8994(98)00140-4
State	Published - Mar 1 1999

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Neurology
Developmental Neuroscience
Clinical Neurology

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10.1016/S0887-8994(98)00140-4

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abstract = "Trihexyphenidyl has been found to be an effective treatment for dystonic movement disorders, improving gross motor function in patients with axial and torsional dystonia, tremors, and myoclonus. In this report, improvements in fine motor control, language, and oral motor skills are described with trihexyphenidyl in an 8-year-old female who developed dystonia after spontaneous bilateral putamenal hemorrhages. No adverse side effects occurred. The mechanism of action of trihexyphenidyl is believed to be in the basal ganglia where it inhibits muscarinic cholinergic receptors and increases the turnover of dopamine.",

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AU - Johnston, Michael V.

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AB - Trihexyphenidyl has been found to be an effective treatment for dystonic movement disorders, improving gross motor function in patients with axial and torsional dystonia, tremors, and myoclonus. In this report, improvements in fine motor control, language, and oral motor skills are described with trihexyphenidyl in an 8-year-old female who developed dystonia after spontaneous bilateral putamenal hemorrhages. No adverse side effects occurred. The mechanism of action of trihexyphenidyl is believed to be in the basal ganglia where it inhibits muscarinic cholinergic receptors and increases the turnover of dopamine.

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Trihexyphenidyl in posthemorrhagic dystonia: Motor and language effects

Abstract

ASJC Scopus subject areas

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