Trihexyphenidyl dependence

M. McInnis, H. Petursson

    Research output: Contribution to journalArticle

    Abstract

    ABSTRACT– Trihexyphenidyl, a synthetic anticholinergic, is frequently used concurrently with neuroleptics to control extrapyramidal side effects. We present two case reports of trihexyphenidyl abuse which concur with the increasing concern expressed regarding the abuse potential of trihexyphenidyl. In one of the cases a double‐blind, placebo‐controlled withdrawal was conducted and monitored on a number of physiological parameters and the Hamilton Anxiety Rating Scale. A recognizable withdrawal syndrome followed discontinuation of the drug. In addition to the abuse potential it is suggested that dependence liability be considered in maintenance therapy with trihexyphenidyl and other antiparkinsonians.

    Original languageEnglish (US)
    Pages (from-to)538-542
    Number of pages5
    JournalActa Psychiatrica Scandinavica
    Volume69
    Issue number6
    DOIs
    StatePublished - Jun 1984

    Keywords

    • Trihexyphenidyl abuse
    • anti‐parkinsonian maintenance therapy
    • dependence
    • toxic psychosis
    • withdrawal

    ASJC Scopus subject areas

    • Psychiatry and Mental health

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