Tricyclic antidepressants: Therapeutic properties and affinity for α-noradrenergic receptor binding sites in the brain

David C. U'Prichard, David A. Greenberg, Peter P. Sheehan, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

Tricyclic antidepressants vary in their capacity to cause psychomotor activation, to relieve agitated depressive states, and to cause sedation and hypotension. We have quantified relative potencies of tricyclic antidepressants in competing for the binding of 3H-labeled WB-4101 to α-noradrenergic receptor sites in rat brain membranes. Affinities of tricyclic drugs for α-noradrenergic receptor sites in the brain correlate well with the capacity of these agents to relieve psychomotor agitation and to induce sedation and hypotension; these affinities also correlate inversely with tendencies to elicit psychomotor activation.

Original languageEnglish (US)
Pages (from-to)197-198
Number of pages2
JournalScience
Volume199
Issue number4325
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • General

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