Trichosporon beigelii, an emerging pathogen resistant to amphotericin B

T. J. Walsh, G. P. Melcher, M. G. Rinaldi, J. Lecciones, D. A. McGough, P. Kelly, J. Lee, D. Callender, M. Rubin, P. A. Pisso

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Abstract

Trichosporon beigelii caused fatal disseminated infections that were resistant to amphotericin B in two granulocytopenic patients. In vitro susceptibility studies demonstrated that both index strains of T. beigelii were inhibited but not killed by amphotericin B at achievable concentrations in serum. The minimum lethal concentration for both isolates was ≥ 18 μg/ml. Five of seven other isolates were found to have a similar pattern of amphotericin B resistance. The fact that the minimum lethal concentration of T. beigelii was many times greater than its MIC was consistent with a resistance pattern of tolerance. We concluded that T. beigelii may be resisitant in vitro to amphotericin B and that this in vitro resistance was correlated with refractory, disseminated trichosporonosis in granulocytopenic patients. T. beigelii should be included in the expanding list of amphotericin B-resistant fungi.

Original languageEnglish (US)
Pages (from-to)1616-1622
Number of pages7
JournalJournal of clinical microbiology
Volume28
Issue number7
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Microbiology (medical)

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    Walsh, T. J., Melcher, G. P., Rinaldi, M. G., Lecciones, J., McGough, D. A., Kelly, P., Lee, J., Callender, D., Rubin, M., & Pisso, P. A. (1990). Trichosporon beigelii, an emerging pathogen resistant to amphotericin B. Journal of clinical microbiology, 28(7), 1616-1622. https://doi.org/10.1128/jcm.28.7.1616-1622.1990