TY - JOUR
T1 - Triazolam and ethanol interaction
T2 - Kinetic and dynamic consequences
AU - Dorian, Paul
AU - Sellers, Edward M.
AU - Kaplan, Howard L.
AU - Hamilton, Carolyn
AU - Greenblatt, David J.
AU - Abernethy, Darrell
PY - 1985/5
Y1 - 1985/5
N2 - The kinetic and dynamic consequences of the coadministration of triazolam and ethanol were investigated in six normal subjects. Each received three treatments: triazolam, 0.25 mg by mouth, preceded by 1 hour and followed for 7.5 hours by oral ethanol dosed to maintain breath concentrations of 800 to 950 mg/L; placebo and ethanol; and triazolam and orange juice. After ethanol, triazolam total AUC0-∞ increased X̄ ± SD = 21% ± 18%). Subjects showed greater psychomotor impairment on measures of free recall, postural stability, and hand-eye coordination after the combination than after either drug alone. These dynamic interactions are greater than the kinetic changes.
AB - The kinetic and dynamic consequences of the coadministration of triazolam and ethanol were investigated in six normal subjects. Each received three treatments: triazolam, 0.25 mg by mouth, preceded by 1 hour and followed for 7.5 hours by oral ethanol dosed to maintain breath concentrations of 800 to 950 mg/L; placebo and ethanol; and triazolam and orange juice. After ethanol, triazolam total AUC0-∞ increased X̄ ± SD = 21% ± 18%). Subjects showed greater psychomotor impairment on measures of free recall, postural stability, and hand-eye coordination after the combination than after either drug alone. These dynamic interactions are greater than the kinetic changes.
UR - http://www.scopus.com/inward/record.url?scp=0021846822&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021846822&partnerID=8YFLogxK
U2 - 10.1038/clpt.1985.88
DO - 10.1038/clpt.1985.88
M3 - Article
C2 - 2859136
AN - SCOPUS:0021846822
SN - 0009-9236
VL - 37
SP - 558
EP - 562
JO - Clinical pharmacology and therapeutics
JF - Clinical pharmacology and therapeutics
IS - 5
ER -