Triazolam and ethanol interaction: Kinetic and dynamic consequences

Paul Dorian, Edward M. Sellers, Howard L. Kaplan, Carolyn Hamilton, David J. Greenblatt, Darrell Abernethy

Research output: Contribution to journalArticle

Abstract

The kinetic and dynamic consequences of the coadministration of triazolam and ethanol were investigated in six normal subjects. Each received three treatments: triazolam, 0.25 mg by mouth, preceded by 1 hour and followed for 7.5 hours by oral ethanol dosed to maintain breath concentrations of 800 to 950 mg/L; placebo and ethanol; and triazolam and orange juice. After ethanol, triazolam total AUC0-∞ increased X̄ ± SD = 21% ± 18%). Subjects showed greater psychomotor impairment on measures of free recall, postural stability, and hand-eye coordination after the combination than after either drug alone. These dynamic interactions are greater than the kinetic changes.

Original languageEnglish (US)
Pages (from-to)558-562
Number of pages5
JournalClinical pharmacology and therapeutics
Volume37
Issue number5
DOIs
StatePublished - May 1985

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Dorian, P., Sellers, E. M., Kaplan, H. L., Hamilton, C., Greenblatt, D. J., & Abernethy, D. (1985). Triazolam and ethanol interaction: Kinetic and dynamic consequences. Clinical pharmacology and therapeutics, 37(5), 558-562. https://doi.org/10.1038/clpt.1985.88