Immunotherapy (desensitization) of hay fever with aqueous extracts of pollen is limited to rather small immunizing doses because of the risk of allergic or anaphylactic reactions. Alum-precipitated pollen extracts are absorbed more slowly, and larger doses may be given in fewer injections with a reduced rate of untoward systemic reactions. In a controlled study, alum-precipitated ragweed extract gave therapeutic results in fall hay fever equal to those obtained with aqueous ragweed extract. Immunologic responses to the two types of extract (measured by the technique of histamine release from isolated washed leukocytes) were also similar. Safer antigen preparations which permit higher doses need to be sought further.
ASJC Scopus subject areas
- Immunology and Allergy