TY - JOUR
T1 - Trials of alum-precipitated pollen extracts in the treatment of hay fever
AU - Norman, Philip S.
AU - Winkenwerder, Walter L.
AU - Lichtenstein, Lawrence M.
N1 - Funding Information:
B the Clinical Immunology varsity, and The Good Samaritan OQoal; Samaritan Hospital, Publication 13u prted by Grants AI 04866 and 9 nfectlous Diseases and by a grant d for publication Jan. 4, 1972. requests to: Dr. Norman, The Good lore, Md. 21212. nts ?f Research Career Development nfectlous Diseases during the performance hout this paper, when dosage in therapy We in a preseasonal series of injections.
PY - 1972/7
Y1 - 1972/7
N2 - Immunotherapy (desensitization) of hay fever with aqueous extracts of pollen is limited to rather small immunizing doses because of the risk of allergic or anaphylactic reactions. Alum-precipitated pollen extracts are absorbed more slowly, and larger doses may be given in fewer injections with a reduced rate of untoward systemic reactions. In a controlled study, alum-precipitated ragweed extract gave therapeutic results in fall hay fever equal to those obtained with aqueous ragweed extract. Immunologic responses to the two types of extract (measured by the technique of histamine release from isolated washed leukocytes) were also similar. Safer antigen preparations which permit higher doses need to be sought further.
AB - Immunotherapy (desensitization) of hay fever with aqueous extracts of pollen is limited to rather small immunizing doses because of the risk of allergic or anaphylactic reactions. Alum-precipitated pollen extracts are absorbed more slowly, and larger doses may be given in fewer injections with a reduced rate of untoward systemic reactions. In a controlled study, alum-precipitated ragweed extract gave therapeutic results in fall hay fever equal to those obtained with aqueous ragweed extract. Immunologic responses to the two types of extract (measured by the technique of histamine release from isolated washed leukocytes) were also similar. Safer antigen preparations which permit higher doses need to be sought further.
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U2 - 10.1016/0091-6749(72)90077-2
DO - 10.1016/0091-6749(72)90077-2
M3 - Article
C2 - 4113507
AN - SCOPUS:0015362651
SN - 0091-6749
VL - 50
SP - 31
EP - 44
JO - The Journal of allergy and clinical immunology
JF - The Journal of allergy and clinical immunology
IS - 1
ER -