Studienendpunkte bei der chronisch-obstruktiven lungenerkrankung (COPD): "Minimal clinically important difference"

Translated title of the contribution: Trial end-point in chronic obstructive pulmonary disease (COPD): Minimal clinically important difference

Adrian Gillissen, R. Buhl, P. Kardos, M. Puhan, K. F. Rabe, T. Rothe, R. Sauer, T. Welte, H. Worth, G. Menz

Research output: Contribution to journalArticle

Abstract

The concept of the minimal clinically important difference (MCID) is intended to provide a measure of relevance for a statistically applied in patients with COPD. Clinically important differences are those differences relevant to the individual patient and important to the patient's life. However, people's difference in a diagnostic parameter perception of what is important vary. Furthermore, physicians may rate the significance of a particular marker and its difference which can be achieved by a pharmacological intervention differently from the patient. Thus, the major problem with defining an MCID for any measure is that the most important differences, which require the most subtle measures for an individual patient, are likely to have the least general application. Conversely, measures that can be generalised are unlikely to have much individual importance and will be very crude tools for an individual assessment. In medical trials both, statistical rigor and clinical relevance are generally required, and MCID is without doubt a key application tool defining treatment success or treatment failure. This paper gives an update on the concept of a minimal important difference of most relevant parameters in COPD treatment.

Translated title of the contributionTrial end-point in chronic obstructive pulmonary disease (COPD): Minimal clinically important difference
Original languageGerman
Pages (from-to)149-157
Number of pages9
JournalPneumologie
Volume62
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Medicine(all)

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    Gillissen, A., Buhl, R., Kardos, P., Puhan, M., Rabe, K. F., Rothe, T., Sauer, R., Welte, T., Worth, H., & Menz, G. (2008). Studienendpunkte bei der chronisch-obstruktiven lungenerkrankung (COPD): "Minimal clinically important difference". Pneumologie, 62(3), 149-157. https://doi.org/10.1055/s-2007-996182