Triad of acute infusion-related reactions associated with liposomal amphotericin B: Analysis of clinical and epidemiological characteristics

Maureen M. Roden; Lucienne D. Nelson; Tena A. Knudsen; Paul F. Jarosinski; Judith M. Starling; Stacey E. Shiflett; Karim Calis; Robert DeChristoforo; Gerald R. Donowitz; Donald Buell; Thomas J. Walsh

doi:10.1086/374553

Triad of acute infusion-related reactions associated with liposomal amphotericin B: Analysis of clinical and epidemiological characteristics

Maureen M. Roden, Lucienne D. Nelson, Tena A. Knudsen, Paul F. Jarosinski, Judith M. Starling, Stacey E. Shiflett, Karim Calis, Robert DeChristoforo, Gerald R. Donowitz, Donald Buell, Thomas J. Walsh

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64 Scopus citations

Abstract

We investigated the clinical characteristics and treatment of patients with a distinctive triad of acute infusion-related reactions (AIRRs) to liposomal amphotericin B (L-AMB) via single-center and multicenter analyses. AIRRs occurred alone or in combination within 1 of 3 symptom complexes: (1) chest pain, dyspnea, and hypoxia; (2) severe abdomen, flank, or leg pain; and (3) flushing and urticaria. The frequency of AIRRs in the single-center analysis increased over time. Most AIRRs (86%) occurred within the first 5 min of infusion. All patients experienced rapid resolution of symptoms after intravenous diphenhydramine was administered. The multicenter analysis demonstrated a mean overall frequency of 20% (range, 0%-100%) of AIRRs among 64 centers. A triad of severe AIRRs to L-AMB may occur in some centers; most of these reactions may be effectively managed by diphenhydramine administration and interruption of L-AMB infusion.

Original language	English (US)
Pages (from-to)	1213-1220
Number of pages	8
Journal	Clinical Infectious Diseases
Volume	36
Issue number	10
DOIs	https://doi.org/10.1086/374553
State	Published - May 15 2003
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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Roden, M. M., Nelson, L. D., Knudsen, T. A., Jarosinski, P. F., Starling, J. M., Shiflett, S. E., Calis, K., DeChristoforo, R., Donowitz, G. R., Buell, D., & Walsh, T. J. (2003). Triad of acute infusion-related reactions associated with liposomal amphotericin B: Analysis of clinical and epidemiological characteristics. Clinical Infectious Diseases, 36(10), 1213-1220. https://doi.org/10.1086/374553

Roden, MM, Nelson, LD, Knudsen, TA, Jarosinski, PF, Starling, JM, Shiflett, SE, Calis, K, DeChristoforo, R, Donowitz, GR, Buell, D & Walsh, TJ 2003, 'Triad of acute infusion-related reactions associated with liposomal amphotericin B: Analysis of clinical and epidemiological characteristics', Clinical Infectious Diseases, vol. 36, no. 10, pp. 1213-1220. https://doi.org/10.1086/374553

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abstract = "We investigated the clinical characteristics and treatment of patients with a distinctive triad of acute infusion-related reactions (AIRRs) to liposomal amphotericin B (L-AMB) via single-center and multicenter analyses. AIRRs occurred alone or in combination within 1 of 3 symptom complexes: (1) chest pain, dyspnea, and hypoxia; (2) severe abdomen, flank, or leg pain; and (3) flushing and urticaria. The frequency of AIRRs in the single-center analysis increased over time. Most AIRRs (86%) occurred within the first 5 min of infusion. All patients experienced rapid resolution of symptoms after intravenous diphenhydramine was administered. The multicenter analysis demonstrated a mean overall frequency of 20% (range, 0%-100%) of AIRRs among 64 centers. A triad of severe AIRRs to L-AMB may occur in some centers; most of these reactions may be effectively managed by diphenhydramine administration and interruption of L-AMB infusion.",

author = "Roden, {Maureen M.} and Nelson, {Lucienne D.} and Knudsen, {Tena A.} and Jarosinski, {Paul F.} and Starling, {Judith M.} and Shiflett, {Stacey E.} and Karim Calis and Robert DeChristoforo and Donowitz, {Gerald R.} and Donald Buell and Walsh, {Thomas J.}",

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AU - Calis, Karim

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AU - Donowitz, Gerald R.

AU - Buell, Donald

AU - Walsh, Thomas J.

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Triad of acute infusion-related reactions associated with liposomal amphotericin B: Analysis of clinical and epidemiological characteristics

Abstract

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