Abstract
Tretinoin is often prescribed before laser resurfacing in an attempt to enhance results. We sought to assess the clinical and biochemical effects of preoperative tretinoin use before laser resurfacing. Patients were randomized to apply tretinoin to one forearm and placebo to the other for 3 weeks. Patients' photodamaged forearms were focally treated by carbon-dioxide laser resurfacing. Biopsy specimens were obtained at baseline and various times posttreatment. Real-time polymerase chain reaction technology was used to quantify messenger RNA levels of types I and III procollagen and matrix metalloproteinases-1, 3, and 9. Wounds were assessed for degree of re-epithelialization using a computer graphics-generated template. A colorimeter was used to quantify postoperative erythema. No substantial differences in either biochemical markers or clinical end points were identified between tretinoin and placebo pretreated forearms. We found no evidence of enhanced collagen formation, accelerated re-epithelialization, or quicker resolution of postoperative erythema with tretinoin pretreatment before laser resurfacing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 940-946 |
| Number of pages | 7 |
| Journal | Journal of the American Academy of Dermatology |
| Volume | 51 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2004 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Dermatology
Cite this
Tretinoin treatment before carbon-dioxide laser resurfacing : A clinical and biochemical analysis. / Orringer, Jeffrey S.; Kang, Sewon; Johnson, Timothy M.; Karimipour, Darius J.; Hamilton, Ted; Hammerberg, Craig; Voorhees, John J.; Fisher, Gary J.
In: Journal of the American Academy of Dermatology, Vol. 51, No. 6, 12.2004, p. 940-946.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tretinoin treatment before carbon-dioxide laser resurfacing
T2 - A clinical and biochemical analysis
AU - Orringer, Jeffrey S.
AU - Kang, Sewon
AU - Johnson, Timothy M.
AU - Karimipour, Darius J.
AU - Hamilton, Ted
AU - Hammerberg, Craig
AU - Voorhees, John J.
AU - Fisher, Gary J.
PY - 2004/12
Y1 - 2004/12
N2 - Tretinoin is often prescribed before laser resurfacing in an attempt to enhance results. We sought to assess the clinical and biochemical effects of preoperative tretinoin use before laser resurfacing. Patients were randomized to apply tretinoin to one forearm and placebo to the other for 3 weeks. Patients' photodamaged forearms were focally treated by carbon-dioxide laser resurfacing. Biopsy specimens were obtained at baseline and various times posttreatment. Real-time polymerase chain reaction technology was used to quantify messenger RNA levels of types I and III procollagen and matrix metalloproteinases-1, 3, and 9. Wounds were assessed for degree of re-epithelialization using a computer graphics-generated template. A colorimeter was used to quantify postoperative erythema. No substantial differences in either biochemical markers or clinical end points were identified between tretinoin and placebo pretreated forearms. We found no evidence of enhanced collagen formation, accelerated re-epithelialization, or quicker resolution of postoperative erythema with tretinoin pretreatment before laser resurfacing.
AB - Tretinoin is often prescribed before laser resurfacing in an attempt to enhance results. We sought to assess the clinical and biochemical effects of preoperative tretinoin use before laser resurfacing. Patients were randomized to apply tretinoin to one forearm and placebo to the other for 3 weeks. Patients' photodamaged forearms were focally treated by carbon-dioxide laser resurfacing. Biopsy specimens were obtained at baseline and various times posttreatment. Real-time polymerase chain reaction technology was used to quantify messenger RNA levels of types I and III procollagen and matrix metalloproteinases-1, 3, and 9. Wounds were assessed for degree of re-epithelialization using a computer graphics-generated template. A colorimeter was used to quantify postoperative erythema. No substantial differences in either biochemical markers or clinical end points were identified between tretinoin and placebo pretreated forearms. We found no evidence of enhanced collagen formation, accelerated re-epithelialization, or quicker resolution of postoperative erythema with tretinoin pretreatment before laser resurfacing.
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UR - http://www.scopus.com/inward/citedby.url?scp=9944238351&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2004.04.040
DO - 10.1016/j.jaad.2004.04.040
M3 - Article
C2 - 15583586
AN - SCOPUS:9944238351
VL - 51
SP - 940
EP - 946
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
SN - 0190-9622
IS - 6
ER -