Trends in prevalence of advanced HIV disease at antiretroviral therapy enrollment - 10 countries, 2004-2015

Andrew F. Auld; Ray W. Shiraishi; Ikwo Oboho; Christine Ross; Moses Bateganya; Valerie Pelletier; Jacob Dee; Kesner Francois; Nirva Duval; Mayer Antoine; Chris Delcher; Gracia Desforges; Mark Griswold; Jean Wysler Domercant; Nadjy Joseph; Varough Deyde; Yrvel Desir; Joelle Deas Van Onacker; Ermane Robin; Helen Chun; Isaac Zulu; Ishani Pathmanathan; E. Kainne Dokubo; Spencer Lloyd; Rituparna Pati; Jonathan Kaplan; Elliot Raizes; Thomas Spira; Kiren Mitruka; Aleny Couto; Eduardo Samo Gudo; Francisco Mbofana; Melissa Briggs; Charity Alfredo; Carla Xavier; Alfredo Vergara; Ndapewa Hamunime; Simon Agolory; Gram Mutandi; Naemi N. Shoopala; Souleymane Sawadogo; Andrew L. Baughman; Adebobola Bashorun; Ibrahim Dalhatu; Mahesh Swaminathan; Dennis Onotu; Solomon Odafe; Oseni Omomo Abiri; Henry H. Debem; Hank Tomlinson; Velephi Okello; Peter Preko; Trong Ao; Caroline Ryan; George Bicego; Peter Ehrenkranz; Harrison Kamiru; Harriet Nuwagaba-Biribonwoha; Gideon Kwesigabo; Angela A. Ramadhani; Kahemele Ng’wangu; Patrick Swai; Mohamed Mfaume; Ramadhani Gongo; Deborah Carpenter; Timothy D. Mastro; Carol Hamilton; Julie Denison; Fred Wabwire-Mangen; Olivier Koole; Kwasi Torpey; Seymour G. Williams; Robert Colebunders; Julius N. Kalamya; Alice Namale; Michelle R. Adler; Bridget Mugisa; Sundeep Gupta; Sharon Tsui; Eric Van Praag; Duc B. Nguyen; Sheryl Lyss; Yen Le; Abu S. Abdul-Quader; Nhan T. Do; Modest Mulenga; Sebastian Hachizovu; Owen Mugurungi; Beth A. Tippett Barr; Elizabeth Gonese; Tsitsi Mutasa-Apollo; Shirish Balachandra; Stephanie Behel; Trista Bingham; Duncan Mackellar; David Lowrance; Tedd V. Ellerbrock

doi:10.15585/mmwr.mm6621a3

Trends in prevalence of advanced HIV disease at antiretroviral therapy enrollment - 10 countries, 2004-2015

Andrew F. Auld, Ray W. Shiraishi, Ikwo Oboho, Christine Ross, Moses Bateganya, Valerie Pelletier, Jacob Dee, Kesner Francois, Nirva Duval, Mayer Antoine, Chris Delcher, Gracia Desforges, Mark Griswold, Jean Wysler Domercant, Nadjy Joseph, Varough Deyde, Yrvel Desir, Joelle Deas Van Onacker, Ermane Robin, Helen ChunIsaac Zulu, Ishani Pathmanathan, E. Kainne Dokubo, Spencer Lloyd, Rituparna Pati, Jonathan Kaplan, Elliot Raizes, Thomas Spira, Kiren Mitruka, Aleny Couto, Eduardo Samo Gudo, Francisco Mbofana, Melissa Briggs, Charity Alfredo, Carla Xavier, Alfredo Vergara, Ndapewa Hamunime, Simon Agolory, Gram Mutandi, Naemi N. Shoopala, Souleymane Sawadogo, Andrew L. Baughman, Adebobola Bashorun, Ibrahim Dalhatu, Mahesh Swaminathan, Dennis Onotu, Solomon Odafe, Oseni Omomo Abiri, Henry H. Debem, Hank Tomlinson, Velephi Okello, Peter Preko, Trong Ao, Caroline Ryan, George Bicego, Peter Ehrenkranz, Harrison Kamiru, Harriet Nuwagaba-Biribonwoha, Gideon Kwesigabo, Angela A. Ramadhani, Kahemele Ng’wangu, Patrick Swai, Mohamed Mfaume, Ramadhani Gongo, Deborah Carpenter, Timothy D. Mastro, Carol Hamilton, Julie Denison, Fred Wabwire-Mangen, Olivier Koole, Kwasi Torpey, Seymour G. Williams, Robert Colebunders, Julius N. Kalamya, Alice Namale, Michelle R. Adler, Bridget Mugisa, Sundeep Gupta, Sharon Tsui, Eric Van Praag, Duc B. Nguyen, Sheryl Lyss, Yen Le, Abu S. Abdul-Quader, Nhan T. Do, Modest Mulenga, Sebastian Hachizovu, Owen Mugurungi, Beth A. Tippett Barr, Elizabeth Gonese, Tsitsi Mutasa-Apollo, Shirish Balachandra, Stephanie Behel, Trista Bingham, Duncan Mackellar, David Lowrance, Tedd V. Ellerbrock

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

What is already known about this topic? Monitoring prevalence of advanced human immunodeficiency virus (HIV) disease (i.e., CD4+ T-cell count <200 cells/µL) among persons initiating antiretroviral therapy (ART) is important to help understand ART program outcomes, inform HIV prevention strategies, and forecast need for adjunctive therapies. What is added by this report? In an analysis of 694,138 adult ART records from 10 countries, the prevalence of advanced disease at ART initiation during 2004-2015 declined in eight countries. In Mozambique (2004-2014), Namibia (2004-2012), and Haiti (2004-2015), prevalence of advanced disease at ART initiation declined from 73% to 37% (p<0.001), 80% to 41% (p<0.001), and 75% to 34% (p<0.001), respectively. In the remaining seven countries with data available for 2004-2011, significant declines in prevalence of advanced disease were observed in Nigeria, Swaziland, Uganda, Vietnam, and Zimbabwe. What are the implications for public health practice? Declines in the prevalence of advanced disease at ART enrollment over time in most countries are encouraging, but in 2015, approximately a third of new ART patients still initiated ART late. Adoption of World Health Organization-recommended “treat-all” guidelines and strategies to facilitate earlier HIV testing, and treatment are needed. These strategies would help reduce HIV-related mortality and HIV incidence.

Original language	English (US)
Pages (from-to)	558-563
Number of pages	6
Journal	Morbidity and Mortality Weekly Report
Volume	66
Issue number	21
DOIs	https://doi.org/10.15585/mmwr.mm6621a3
State	Published - Jun 2 2017
Externally published	Yes

ASJC Scopus subject areas

Health(social science)
Health Information Management
Health, Toxicology and Mutagenesis
Epidemiology

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10.15585/mmwr.mm6621a3

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Auld, A. F., Shiraishi, R. W., Oboho, I., Ross, C., Bateganya, M., Pelletier, V., Dee, J., Francois, K., Duval, N., Antoine, M., Delcher, C., Desforges, G., Griswold, M., Domercant, J. W., Joseph, N., Deyde, V., Desir, Y., Van Onacker, J. D., Robin, E., ... Ellerbrock, T. V. (2017). Trends in prevalence of advanced HIV disease at antiretroviral therapy enrollment - 10 countries, 2004-2015. Morbidity and Mortality Weekly Report, 66(21), 558-563. https://doi.org/10.15585/mmwr.mm6621a3

Auld, AF, Shiraishi, RW, Oboho, I, Ross, C, Bateganya, M, Pelletier, V, Dee, J, Francois, K, Duval, N, Antoine, M, Delcher, C, Desforges, G, Griswold, M, Domercant, JW, Joseph, N, Deyde, V, Desir, Y, Van Onacker, JD, Robin, E, Chun, H, Zulu, I, Pathmanathan, I, Kainne Dokubo, E, Lloyd, S, Pati, R, Kaplan, J, Raizes, E, Spira, T, Mitruka, K, Couto, A, Gudo, ES, Mbofana, F, Briggs, M, Alfredo, C, Xavier, C, Vergara, A, Hamunime, N, Agolory, S, Mutandi, G, Shoopala, NN, Sawadogo, S, Baughman, AL, Bashorun, A, Dalhatu, I, Swaminathan, M, Onotu, D, Odafe, S, Abiri, OO, Debem, HH, Tomlinson, H, Okello, V, Preko, P, Ao, T, Ryan, C, Bicego, G, Ehrenkranz, P, Kamiru, H, Nuwagaba-Biribonwoha, H, Kwesigabo, G, Ramadhani, AA, Ng’wangu, K, Swai, P, Mfaume, M, Gongo, R, Carpenter, D, Mastro, TD, Hamilton, C, Denison, J, Wabwire-Mangen, F, Koole, O, Torpey, K, Williams, SG, Colebunders, R, Kalamya, JN, Namale, A, Adler, MR, Mugisa, B, Gupta, S, Tsui, S, Van Praag, E, Nguyen, DB, Lyss, S, Le, Y, Abdul-Quader, AS, Do, NT, Mulenga, M, Hachizovu, S, Mugurungi, O, Tippett Barr, BA, Gonese, E, Mutasa-Apollo, T, Balachandra, S, Behel, S, Bingham, T, Mackellar, D, Lowrance, D & Ellerbrock, TV 2017, 'Trends in prevalence of advanced HIV disease at antiretroviral therapy enrollment - 10 countries, 2004-2015', Morbidity and Mortality Weekly Report, vol. 66, no. 21, pp. 558-563. https://doi.org/10.15585/mmwr.mm6621a3

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title = "Trends in prevalence of advanced HIV disease at antiretroviral therapy enrollment - 10 countries, 2004-2015",

abstract = "What is already known about this topic? Monitoring prevalence of advanced human immunodeficiency virus (HIV) disease (i.e., CD4+ T-cell count <200 cells/µL) among persons initiating antiretroviral therapy (ART) is important to help understand ART program outcomes, inform HIV prevention strategies, and forecast need for adjunctive therapies. What is added by this report? In an analysis of 694,138 adult ART records from 10 countries, the prevalence of advanced disease at ART initiation during 2004-2015 declined in eight countries. In Mozambique (2004-2014), Namibia (2004-2012), and Haiti (2004-2015), prevalence of advanced disease at ART initiation declined from 73% to 37% (p<0.001), 80% to 41% (p<0.001), and 75% to 34% (p<0.001), respectively. In the remaining seven countries with data available for 2004-2011, significant declines in prevalence of advanced disease were observed in Nigeria, Swaziland, Uganda, Vietnam, and Zimbabwe. What are the implications for public health practice? Declines in the prevalence of advanced disease at ART enrollment over time in most countries are encouraging, but in 2015, approximately a third of new ART patients still initiated ART late. Adoption of World Health Organization-recommended “treat-all” guidelines and strategies to facilitate earlier HIV testing, and treatment are needed. These strategies would help reduce HIV-related mortality and HIV incidence.",

author = "Auld, {Andrew F.} and Shiraishi, {Ray W.} and Ikwo Oboho and Christine Ross and Moses Bateganya and Valerie Pelletier and Jacob Dee and Kesner Francois and Nirva Duval and Mayer Antoine and Chris Delcher and Gracia Desforges and Mark Griswold and Domercant, {Jean Wysler} and Nadjy Joseph and Varough Deyde and Yrvel Desir and {Van Onacker}, {Joelle Deas} and Ermane Robin and Helen Chun and Isaac Zulu and Ishani Pathmanathan and {Kainne Dokubo}, E. and Spencer Lloyd and Rituparna Pati and Jonathan Kaplan and Elliot Raizes and Thomas Spira and Kiren Mitruka and Aleny Couto and Gudo, {Eduardo Samo} and Francisco Mbofana and Melissa Briggs and Charity Alfredo and Carla Xavier and Alfredo Vergara and Ndapewa Hamunime and Simon Agolory and Gram Mutandi and Shoopala, {Naemi N.} and Souleymane Sawadogo and Baughman, {Andrew L.} and Adebobola Bashorun and Ibrahim Dalhatu and Mahesh Swaminathan and Dennis Onotu and Solomon Odafe and Abiri, {Oseni Omomo} and Debem, {Henry H.} and Hank Tomlinson and Velephi Okello and Peter Preko and Trong Ao and Caroline Ryan and George Bicego and Peter Ehrenkranz and Harrison Kamiru and Harriet Nuwagaba-Biribonwoha and Gideon Kwesigabo and Ramadhani, {Angela A.} and Kahemele Ng{\textquoteright}wangu and Patrick Swai and Mohamed Mfaume and Ramadhani Gongo and Deborah Carpenter and Mastro, {Timothy D.} and Carol Hamilton and Julie Denison and Fred Wabwire-Mangen and Olivier Koole and Kwasi Torpey and Williams, {Seymour G.} and Robert Colebunders and Kalamya, {Julius N.} and Alice Namale and Adler, {Michelle R.} and Bridget Mugisa and Sundeep Gupta and Sharon Tsui and {Van Praag}, Eric and Nguyen, {Duc B.} and Sheryl Lyss and Yen Le and Abdul-Quader, {Abu S.} and Do, {Nhan T.} and Modest Mulenga and Sebastian Hachizovu and Owen Mugurungi and {Tippett Barr}, {Beth A.} and Elizabeth Gonese and Tsitsi Mutasa-Apollo and Shirish Balachandra and Stephanie Behel and Trista Bingham and Duncan Mackellar and David Lowrance and Ellerbrock, {Tedd V.}",

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doi = "10.15585/mmwr.mm6621a3",

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T1 - Trends in prevalence of advanced HIV disease at antiretroviral therapy enrollment - 10 countries, 2004-2015

AU - Auld, Andrew F.

AU - Shiraishi, Ray W.

AU - Oboho, Ikwo

AU - Ross, Christine

AU - Bateganya, Moses

AU - Pelletier, Valerie

AU - Dee, Jacob

AU - Francois, Kesner

AU - Duval, Nirva

AU - Antoine, Mayer

AU - Delcher, Chris

AU - Desforges, Gracia

AU - Griswold, Mark

AU - Domercant, Jean Wysler

AU - Joseph, Nadjy

AU - Deyde, Varough

AU - Desir, Yrvel

AU - Van Onacker, Joelle Deas

AU - Robin, Ermane

AU - Chun, Helen

AU - Zulu, Isaac

AU - Pathmanathan, Ishani

AU - Kainne Dokubo, E.

AU - Lloyd, Spencer

AU - Pati, Rituparna

AU - Kaplan, Jonathan

AU - Raizes, Elliot

AU - Spira, Thomas

AU - Mitruka, Kiren

AU - Couto, Aleny

AU - Gudo, Eduardo Samo

AU - Mbofana, Francisco

AU - Briggs, Melissa

AU - Alfredo, Charity

AU - Xavier, Carla

AU - Vergara, Alfredo

AU - Hamunime, Ndapewa

AU - Agolory, Simon

AU - Mutandi, Gram

AU - Shoopala, Naemi N.

AU - Sawadogo, Souleymane

AU - Baughman, Andrew L.

AU - Bashorun, Adebobola

AU - Dalhatu, Ibrahim

AU - Swaminathan, Mahesh

AU - Onotu, Dennis

AU - Odafe, Solomon

AU - Abiri, Oseni Omomo

AU - Debem, Henry H.

AU - Tomlinson, Hank

AU - Okello, Velephi

AU - Preko, Peter

AU - Ao, Trong

AU - Ryan, Caroline

AU - Bicego, George

AU - Ehrenkranz, Peter

AU - Kamiru, Harrison

AU - Nuwagaba-Biribonwoha, Harriet

AU - Kwesigabo, Gideon

AU - Ramadhani, Angela A.

AU - Ng’wangu, Kahemele

AU - Swai, Patrick

AU - Mfaume, Mohamed

AU - Gongo, Ramadhani

AU - Carpenter, Deborah

AU - Mastro, Timothy D.

AU - Hamilton, Carol

AU - Denison, Julie

AU - Wabwire-Mangen, Fred

AU - Koole, Olivier

AU - Torpey, Kwasi

AU - Williams, Seymour G.

AU - Colebunders, Robert

AU - Kalamya, Julius N.

AU - Namale, Alice

AU - Adler, Michelle R.

AU - Mugisa, Bridget

AU - Gupta, Sundeep

AU - Tsui, Sharon

AU - Van Praag, Eric

AU - Nguyen, Duc B.

AU - Lyss, Sheryl

AU - Le, Yen

AU - Abdul-Quader, Abu S.

AU - Do, Nhan T.

AU - Mulenga, Modest

AU - Hachizovu, Sebastian

AU - Mugurungi, Owen

AU - Tippett Barr, Beth A.

AU - Gonese, Elizabeth

AU - Mutasa-Apollo, Tsitsi

AU - Balachandra, Shirish

AU - Behel, Stephanie

AU - Bingham, Trista

AU - Mackellar, Duncan

AU - Lowrance, David

AU - Ellerbrock, Tedd V.

PY - 2017/6/2

Y1 - 2017/6/2

N2 - What is already known about this topic? Monitoring prevalence of advanced human immunodeficiency virus (HIV) disease (i.e., CD4+ T-cell count <200 cells/µL) among persons initiating antiretroviral therapy (ART) is important to help understand ART program outcomes, inform HIV prevention strategies, and forecast need for adjunctive therapies. What is added by this report? In an analysis of 694,138 adult ART records from 10 countries, the prevalence of advanced disease at ART initiation during 2004-2015 declined in eight countries. In Mozambique (2004-2014), Namibia (2004-2012), and Haiti (2004-2015), prevalence of advanced disease at ART initiation declined from 73% to 37% (p<0.001), 80% to 41% (p<0.001), and 75% to 34% (p<0.001), respectively. In the remaining seven countries with data available for 2004-2011, significant declines in prevalence of advanced disease were observed in Nigeria, Swaziland, Uganda, Vietnam, and Zimbabwe. What are the implications for public health practice? Declines in the prevalence of advanced disease at ART enrollment over time in most countries are encouraging, but in 2015, approximately a third of new ART patients still initiated ART late. Adoption of World Health Organization-recommended “treat-all” guidelines and strategies to facilitate earlier HIV testing, and treatment are needed. These strategies would help reduce HIV-related mortality and HIV incidence.

AB - What is already known about this topic? Monitoring prevalence of advanced human immunodeficiency virus (HIV) disease (i.e., CD4+ T-cell count <200 cells/µL) among persons initiating antiretroviral therapy (ART) is important to help understand ART program outcomes, inform HIV prevention strategies, and forecast need for adjunctive therapies. What is added by this report? In an analysis of 694,138 adult ART records from 10 countries, the prevalence of advanced disease at ART initiation during 2004-2015 declined in eight countries. In Mozambique (2004-2014), Namibia (2004-2012), and Haiti (2004-2015), prevalence of advanced disease at ART initiation declined from 73% to 37% (p<0.001), 80% to 41% (p<0.001), and 75% to 34% (p<0.001), respectively. In the remaining seven countries with data available for 2004-2011, significant declines in prevalence of advanced disease were observed in Nigeria, Swaziland, Uganda, Vietnam, and Zimbabwe. What are the implications for public health practice? Declines in the prevalence of advanced disease at ART enrollment over time in most countries are encouraging, but in 2015, approximately a third of new ART patients still initiated ART late. Adoption of World Health Organization-recommended “treat-all” guidelines and strategies to facilitate earlier HIV testing, and treatment are needed. These strategies would help reduce HIV-related mortality and HIV incidence.

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Trends in prevalence of advanced HIV disease at antiretroviral therapy enrollment - 10 countries, 2004-2015

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