Trends in post-liver transplant survival in patients with hepatitis C between 1991 and 2001 in the United States

Paul J. Thuluvath, Karen L. Krok, Dorry Segev, Hwan Y. Yoo

Research output: Contribution to journalArticle

Abstract

It has been suggested that the post-liver transplantation (LT) survival rate of patients with hepatitis C virus infection (HCV) has declined in recent years. To compare the outcome of LT in patients with HCV at various time intervals between 1991 and 2001, we used United Network for Organ Sharing data to compare the post-LT survival of adult patients (age > 18 years) with HCV with those without HCV. Of the 37,101 patients who underwent LT during the study period, 28,193 patients (HCV 7,459 and 20,734 non HCV) were eligible for the study. On the basis of the time of transplantation, patients were divided into 3 groups: 1991-1993 (period 1), 1994-1997 (period 2), and 1998-2001 (period 3). The patient and graft survival rates were adjusted for other known confounding variables that influenced outcomes. The 3-year patient survival rate was lower in HCV patients compared with non-HCV recipients (78.5% vs. 81.4%, hazard ratio 1.14, 95% confidence interval 1.05-1.23, P = 0.001). The graft (72.8%), 71.0%, and 69.8%) and patient (77.4%, 79.6%, and 78.5%) survival of HCV patients remained unchanged during study periods 1-3, respectively. However, the graft and patient survival has remained unchanged between 1991 and 2001 in HCV recipients, but during the same period, there was a great improvement in survival among non-HCV recipients.

Original languageEnglish (US)
Pages (from-to)719-724
Number of pages6
JournalLiver Transplantation
Volume13
Issue number5
DOIs
StatePublished - May 2007

Fingerprint

Hepatitis C
Virus Diseases
Hepacivirus
Transplants
Liver
Liver Transplantation
Survival Rate
Graft Survival
Survival
Confounding Factors (Epidemiology)
Information Dissemination
Transplantation
Confidence Intervals

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Trends in post-liver transplant survival in patients with hepatitis C between 1991 and 2001 in the United States. / Thuluvath, Paul J.; Krok, Karen L.; Segev, Dorry; Yoo, Hwan Y.

In: Liver Transplantation, Vol. 13, No. 5, 05.2007, p. 719-724.

Research output: Contribution to journalArticle

@article{52ffc53483944f1c8d29532a2de7b549,
title = "Trends in post-liver transplant survival in patients with hepatitis C between 1991 and 2001 in the United States",
abstract = "It has been suggested that the post-liver transplantation (LT) survival rate of patients with hepatitis C virus infection (HCV) has declined in recent years. To compare the outcome of LT in patients with HCV at various time intervals between 1991 and 2001, we used United Network for Organ Sharing data to compare the post-LT survival of adult patients (age > 18 years) with HCV with those without HCV. Of the 37,101 patients who underwent LT during the study period, 28,193 patients (HCV 7,459 and 20,734 non HCV) were eligible for the study. On the basis of the time of transplantation, patients were divided into 3 groups: 1991-1993 (period 1), 1994-1997 (period 2), and 1998-2001 (period 3). The patient and graft survival rates were adjusted for other known confounding variables that influenced outcomes. The 3-year patient survival rate was lower in HCV patients compared with non-HCV recipients (78.5{\%} vs. 81.4{\%}, hazard ratio 1.14, 95{\%} confidence interval 1.05-1.23, P = 0.001). The graft (72.8{\%}), 71.0{\%}, and 69.8{\%}) and patient (77.4{\%}, 79.6{\%}, and 78.5{\%}) survival of HCV patients remained unchanged during study periods 1-3, respectively. However, the graft and patient survival has remained unchanged between 1991 and 2001 in HCV recipients, but during the same period, there was a great improvement in survival among non-HCV recipients.",
author = "Thuluvath, {Paul J.} and Krok, {Karen L.} and Dorry Segev and Yoo, {Hwan Y.}",
year = "2007",
month = "5",
doi = "10.1002/lt.21123",
language = "English (US)",
volume = "13",
pages = "719--724",
journal = "Liver Transplantation",
issn = "1527-6465",
publisher = "John Wiley and Sons Ltd",
number = "5",

}

TY - JOUR

T1 - Trends in post-liver transplant survival in patients with hepatitis C between 1991 and 2001 in the United States

AU - Thuluvath, Paul J.

AU - Krok, Karen L.

AU - Segev, Dorry

AU - Yoo, Hwan Y.

PY - 2007/5

Y1 - 2007/5

N2 - It has been suggested that the post-liver transplantation (LT) survival rate of patients with hepatitis C virus infection (HCV) has declined in recent years. To compare the outcome of LT in patients with HCV at various time intervals between 1991 and 2001, we used United Network for Organ Sharing data to compare the post-LT survival of adult patients (age > 18 years) with HCV with those without HCV. Of the 37,101 patients who underwent LT during the study period, 28,193 patients (HCV 7,459 and 20,734 non HCV) were eligible for the study. On the basis of the time of transplantation, patients were divided into 3 groups: 1991-1993 (period 1), 1994-1997 (period 2), and 1998-2001 (period 3). The patient and graft survival rates were adjusted for other known confounding variables that influenced outcomes. The 3-year patient survival rate was lower in HCV patients compared with non-HCV recipients (78.5% vs. 81.4%, hazard ratio 1.14, 95% confidence interval 1.05-1.23, P = 0.001). The graft (72.8%), 71.0%, and 69.8%) and patient (77.4%, 79.6%, and 78.5%) survival of HCV patients remained unchanged during study periods 1-3, respectively. However, the graft and patient survival has remained unchanged between 1991 and 2001 in HCV recipients, but during the same period, there was a great improvement in survival among non-HCV recipients.

AB - It has been suggested that the post-liver transplantation (LT) survival rate of patients with hepatitis C virus infection (HCV) has declined in recent years. To compare the outcome of LT in patients with HCV at various time intervals between 1991 and 2001, we used United Network for Organ Sharing data to compare the post-LT survival of adult patients (age > 18 years) with HCV with those without HCV. Of the 37,101 patients who underwent LT during the study period, 28,193 patients (HCV 7,459 and 20,734 non HCV) were eligible for the study. On the basis of the time of transplantation, patients were divided into 3 groups: 1991-1993 (period 1), 1994-1997 (period 2), and 1998-2001 (period 3). The patient and graft survival rates were adjusted for other known confounding variables that influenced outcomes. The 3-year patient survival rate was lower in HCV patients compared with non-HCV recipients (78.5% vs. 81.4%, hazard ratio 1.14, 95% confidence interval 1.05-1.23, P = 0.001). The graft (72.8%), 71.0%, and 69.8%) and patient (77.4%, 79.6%, and 78.5%) survival of HCV patients remained unchanged during study periods 1-3, respectively. However, the graft and patient survival has remained unchanged between 1991 and 2001 in HCV recipients, but during the same period, there was a great improvement in survival among non-HCV recipients.

UR - http://www.scopus.com/inward/record.url?scp=34249019659&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249019659&partnerID=8YFLogxK

U2 - 10.1002/lt.21123

DO - 10.1002/lt.21123

M3 - Article

C2 - 17457933

AN - SCOPUS:34249019659

VL - 13

SP - 719

EP - 724

JO - Liver Transplantation

JF - Liver Transplantation

SN - 1527-6465

IS - 5

ER -