Trends in hospitalizations for AIDS-associated Pneumocystis jirovecii pneumonia in the United States (1986 to 2005)

Colleen F. Kelley, William Checkley, David M. Mannino, Carlos Franco-Paredes, Carlos Del Rio, Fernando Holguin

Research output: Contribution to journalArticle

Abstract

Background: Although hospitalizations for AIDS-associated Pneumocystis jirovecii pneumonia (PCP) in the United States have decreased since the introduction of chemoprophylaxis and potent combination antiretroviral therapy (ART), PCP remains an important cause of illness and death among AIDS patients. Methods: We analyzed trends in AIDS-associated PCP hospital discharges using the National Hospital Discharge Surveys between 1986 and 2005. Results: An estimated 539 million patients were discharged from hospitals between 1986 and 2005, of whom an estimated 312,411 had AIDS-associated PCP. The proportion of patients discharged from the hospital with AIDS-associated PCP decreased from 31% before the introduction of chemoprophylaxis (1986 to 1989) to 17% with chemoprophylaxis (1990 to 1995) and subsequently to 9% after the introduction of ART in 1996 (p <0.001). Mortality from AIDS-associated PCP decreased from 21 to 16% and subsequently to 7% between these three time periods (p <0.001). Among those who received mechanical ventilation, mortality decreased from 79% in the prechemoprophylaxis era to 31% in the ART era (p <0.001) alongside an increase (from 5 to 11%) in the use of mechanical ventilation. We also observed a shift in the population at-risk for PCP over time: a greater proportion of black people, women, and people from Southern states were affected (all p <0.001). Conclusions: While there have been significant reductions in hospitalizations and hospital mortality for AIDS-associated PCP over the last 20 years, these reductions have not been homogenous across demographic subpopulations and geographic regions and point to new at-risk populations. Furthermore, mortality in severe cases of PCP that require mechanical ventilation has improved substantially.

Original languageEnglish (US)
Pages (from-to)190-197
Number of pages8
JournalChest
Volume136
Issue number1
DOIs
StatePublished - Jul 1 2009

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Pneumocystis carinii
Pneumocystis Pneumonia
Acquired Immunodeficiency Syndrome
Hospitalization
Chemoprevention
Artificial Respiration
Mortality
Health Care Surveys
Hospital Mortality
Cause of Death
Therapeutics
Demography

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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Trends in hospitalizations for AIDS-associated Pneumocystis jirovecii pneumonia in the United States (1986 to 2005). / Kelley, Colleen F.; Checkley, William; Mannino, David M.; Franco-Paredes, Carlos; Del Rio, Carlos; Holguin, Fernando.

In: Chest, Vol. 136, No. 1, 01.07.2009, p. 190-197.

Research output: Contribution to journalArticle

Kelley, Colleen F. ; Checkley, William ; Mannino, David M. ; Franco-Paredes, Carlos ; Del Rio, Carlos ; Holguin, Fernando. / Trends in hospitalizations for AIDS-associated Pneumocystis jirovecii pneumonia in the United States (1986 to 2005). In: Chest. 2009 ; Vol. 136, No. 1. pp. 190-197.
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abstract = "Background: Although hospitalizations for AIDS-associated Pneumocystis jirovecii pneumonia (PCP) in the United States have decreased since the introduction of chemoprophylaxis and potent combination antiretroviral therapy (ART), PCP remains an important cause of illness and death among AIDS patients. Methods: We analyzed trends in AIDS-associated PCP hospital discharges using the National Hospital Discharge Surveys between 1986 and 2005. Results: An estimated 539 million patients were discharged from hospitals between 1986 and 2005, of whom an estimated 312,411 had AIDS-associated PCP. The proportion of patients discharged from the hospital with AIDS-associated PCP decreased from 31{\%} before the introduction of chemoprophylaxis (1986 to 1989) to 17{\%} with chemoprophylaxis (1990 to 1995) and subsequently to 9{\%} after the introduction of ART in 1996 (p <0.001). Mortality from AIDS-associated PCP decreased from 21 to 16{\%} and subsequently to 7{\%} between these three time periods (p <0.001). Among those who received mechanical ventilation, mortality decreased from 79{\%} in the prechemoprophylaxis era to 31{\%} in the ART era (p <0.001) alongside an increase (from 5 to 11{\%}) in the use of mechanical ventilation. We also observed a shift in the population at-risk for PCP over time: a greater proportion of black people, women, and people from Southern states were affected (all p <0.001). Conclusions: While there have been significant reductions in hospitalizations and hospital mortality for AIDS-associated PCP over the last 20 years, these reductions have not been homogenous across demographic subpopulations and geographic regions and point to new at-risk populations. Furthermore, mortality in severe cases of PCP that require mechanical ventilation has improved substantially.",
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