Abstract
There is considerable controversy regarding a putative association between schizophrenia and a biallelic Bali polymorphism in the first exon of the dopamine D3 receptor gene (DRD3), although meta-analyses of published data suggest an association. If such an association exists, it may be detectable at markers physically close to DRD3. Accordingly, we conducted a case-control association study using D3S1310, a short tandem repeat polymorphism located approximately 700 kb telomeric to DRD3 on chromosome 3q13.3. The subjects were Swedish patients with schizophrenia (DSM III-R criteria, n = 110) and screened adult controls (n = 83). A trend for a negative association with the 141 bp allele was detected (X2 = 7.6, d.f. = 1, P = 0.006; odds ratio 0.46, 95% confidence intervals 0.26, 0.81). However, following corrections for multiple comparisons using subgroups (n = 15) the difference was not significant. Also, due to the risk for population stratification in case-control association studies the results must be treated as tentative. If replicated the results may lend further support for the proposition of an association between schizophrenia and DRD3 or a gene in close proximity to DRD3 on chromosome 3q.
Original language | English (US) |
---|---|
Pages (from-to) | 352-357 |
Number of pages | 6 |
Journal | American Journal of Medical Genetics - Neuropsychiatric Genetics |
Volume | 88 |
Issue number | 4 |
DOIs | |
State | Published - Aug 20 1999 |
Keywords
- Association
- Dopamine D receptor gene locus
- Dopamine receptors
- Genetics
- Schizophrenia
ASJC Scopus subject areas
- Genetics(clinical)
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience