Trend for an association between schizophrenia and D3S1310, a marker in proximity to the dopamine D3 receptor gene

E. G. Jönsson, V. L. Nimgaonkar, X. R. Zhang, S. H. Shaw, E. Burgert, M. A. Crocq, A. Chakravarti, G. C. Sedvall

Research output: Contribution to journalArticlepeer-review

Abstract

There is considerable controversy regarding a putative association between schizophrenia and a biallelic Bali polymorphism in the first exon of the dopamine D3 receptor gene (DRD3), although meta-analyses of published data suggest an association. If such an association exists, it may be detectable at markers physically close to DRD3. Accordingly, we conducted a case-control association study using D3S1310, a short tandem repeat polymorphism located approximately 700 kb telomeric to DRD3 on chromosome 3q13.3. The subjects were Swedish patients with schizophrenia (DSM III-R criteria, n = 110) and screened adult controls (n = 83). A trend for a negative association with the 141 bp allele was detected (X2 = 7.6, d.f. = 1, P = 0.006; odds ratio 0.46, 95% confidence intervals 0.26, 0.81). However, following corrections for multiple comparisons using subgroups (n = 15) the difference was not significant. Also, due to the risk for population stratification in case-control association studies the results must be treated as tentative. If replicated the results may lend further support for the proposition of an association between schizophrenia and DRD3 or a gene in close proximity to DRD3 on chromosome 3q.

Original languageEnglish (US)
Pages (from-to)352-357
Number of pages6
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume88
Issue number4
DOIs
StatePublished - Aug 20 1999

Keywords

  • Association
  • Dopamine D receptor gene locus
  • Dopamine receptors
  • Genetics
  • Schizophrenia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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