TY - JOUR
T1 - Tremor
T2 - Role of striatal cholinergic neurons and the effect of intrastriatal kainic acid
AU - Silbergeld, Ellen K.
AU - Hruska, R. E.
PY - 1979/12
Y1 - 1979/12
N2 - Rats injected intrastriatally with kainic acid (KA) showed increased tremor responses to arecoline and tremorine, but not to harmaline. Since KA significantly reduced both pre- and postsynaptic measurements of cholinergic function in the striatum, the results indicate that integrity of the striatal cholinergic system is not essential to tremor response. Further investigations of cholinergic function in the brains of rats injected with KA did not reveal evidence of cholinergic supersensitivity; thus, the altered responses to cholinergic agents may reflect KA-associated destruction of some pathway normally opposing the behavioral output of cholinergic stimulation. If, as recently proposed, intrastriatal injection of KA produces an animal model of Huntington's disease (HD), then these results may also be relevant to experimental therapeutics of this disorder.
AB - Rats injected intrastriatally with kainic acid (KA) showed increased tremor responses to arecoline and tremorine, but not to harmaline. Since KA significantly reduced both pre- and postsynaptic measurements of cholinergic function in the striatum, the results indicate that integrity of the striatal cholinergic system is not essential to tremor response. Further investigations of cholinergic function in the brains of rats injected with KA did not reveal evidence of cholinergic supersensitivity; thus, the altered responses to cholinergic agents may reflect KA-associated destruction of some pathway normally opposing the behavioral output of cholinergic stimulation. If, as recently proposed, intrastriatal injection of KA produces an animal model of Huntington's disease (HD), then these results may also be relevant to experimental therapeutics of this disorder.
UR - http://www.scopus.com/inward/record.url?scp=0018565947&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018565947&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(79)96119-6
DO - 10.1016/0304-3940(79)96119-6
M3 - Article
C2 - 530529
AN - SCOPUS:0018565947
SN - 0304-3940
VL - 15
SP - 235
EP - 242
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2-3
ER -