Abstract
Selective serotonin reuptake inhibitors (SSRIs) are well-established medications for the treatment of mood disorders including major depression. These agents are also known to exhibit potent antiplatelet and endothelium protective effects effects. Additionally, SSRIs can exacerbate the development of inflammation, and modulate the interleukin and interferon production. All of the above suggest that SSRIs therapy could be considered as a potential strategy for the wound healing treatment. We summarized some body of the available data on the history of serotonin metabolism, mechanism of action of ketanserin, and hypothesize why SSRIs may be beneficial in the wound repair natural history. Different pathophysiological considerations are also reflected in this review. Finally, we suggest that the topical use of SSRIs may represent a promising avenue for future strategies affecting wound repair in high-risk patients, especially those with diabetes mellitus, venous insufficiency, obesity, and other vascular disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 103-109 |
| Number of pages | 7 |
| Journal | Medical Hypotheses |
| Volume | 63 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2004 |
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ASJC Scopus subject areas
- Developmental Biology
- Medicine(all)
- Drug Discovery
Cite this
Treatment with selective serotonin reuptake inhibitors for enhancing wound healing. / Malinin, Alex; Oshrine, Benjamin; Serebruany, Victor.
In: Medical Hypotheses, Vol. 63, No. 1, 2004, p. 103-109.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment with selective serotonin reuptake inhibitors for enhancing wound healing
AU - Malinin, Alex
AU - Oshrine, Benjamin
AU - Serebruany, Victor
PY - 2004
Y1 - 2004
N2 - Selective serotonin reuptake inhibitors (SSRIs) are well-established medications for the treatment of mood disorders including major depression. These agents are also known to exhibit potent antiplatelet and endothelium protective effects effects. Additionally, SSRIs can exacerbate the development of inflammation, and modulate the interleukin and interferon production. All of the above suggest that SSRIs therapy could be considered as a potential strategy for the wound healing treatment. We summarized some body of the available data on the history of serotonin metabolism, mechanism of action of ketanserin, and hypothesize why SSRIs may be beneficial in the wound repair natural history. Different pathophysiological considerations are also reflected in this review. Finally, we suggest that the topical use of SSRIs may represent a promising avenue for future strategies affecting wound repair in high-risk patients, especially those with diabetes mellitus, venous insufficiency, obesity, and other vascular disorders.
AB - Selective serotonin reuptake inhibitors (SSRIs) are well-established medications for the treatment of mood disorders including major depression. These agents are also known to exhibit potent antiplatelet and endothelium protective effects effects. Additionally, SSRIs can exacerbate the development of inflammation, and modulate the interleukin and interferon production. All of the above suggest that SSRIs therapy could be considered as a potential strategy for the wound healing treatment. We summarized some body of the available data on the history of serotonin metabolism, mechanism of action of ketanserin, and hypothesize why SSRIs may be beneficial in the wound repair natural history. Different pathophysiological considerations are also reflected in this review. Finally, we suggest that the topical use of SSRIs may represent a promising avenue for future strategies affecting wound repair in high-risk patients, especially those with diabetes mellitus, venous insufficiency, obesity, and other vascular disorders.
UR - http://www.scopus.com/inward/record.url?scp=3042803316&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3042803316&partnerID=8YFLogxK
U2 - 10.1016/j.mehy.2003.10.021
DO - 10.1016/j.mehy.2003.10.021
M3 - Article
C2 - 15193359
AN - SCOPUS:3042803316
VL - 63
SP - 103
EP - 109
JO - Medical Hypotheses
JF - Medical Hypotheses
SN - 0306-9877
IS - 1
ER -