Treatment with selective serotonin reuptake inhibitors for enhancing wound healing

Alex Malinin, Benjamin Oshrine, Victor Serebruany

Research output: Contribution to journalArticle

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are well-established medications for the treatment of mood disorders including major depression. These agents are also known to exhibit potent antiplatelet and endothelium protective effects effects. Additionally, SSRIs can exacerbate the development of inflammation, and modulate the interleukin and interferon production. All of the above suggest that SSRIs therapy could be considered as a potential strategy for the wound healing treatment. We summarized some body of the available data on the history of serotonin metabolism, mechanism of action of ketanserin, and hypothesize why SSRIs may be beneficial in the wound repair natural history. Different pathophysiological considerations are also reflected in this review. Finally, we suggest that the topical use of SSRIs may represent a promising avenue for future strategies affecting wound repair in high-risk patients, especially those with diabetes mellitus, venous insufficiency, obesity, and other vascular disorders.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalMedical Hypotheses
Volume63
Issue number1
DOIs
StatePublished - 2004

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Serotonin Uptake Inhibitors
Wound Healing
Therapeutics
Ketanserin
Venous Insufficiency
Interleukins
Wounds and Injuries
Natural History
Mood Disorders
Interferons
Endothelium
Blood Vessels
Serotonin
Diabetes Mellitus
Obesity
History
Depression
Inflammation

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

Cite this

Treatment with selective serotonin reuptake inhibitors for enhancing wound healing. / Malinin, Alex; Oshrine, Benjamin; Serebruany, Victor.

In: Medical Hypotheses, Vol. 63, No. 1, 2004, p. 103-109.

Research output: Contribution to journalArticle

Malinin, Alex ; Oshrine, Benjamin ; Serebruany, Victor. / Treatment with selective serotonin reuptake inhibitors for enhancing wound healing. In: Medical Hypotheses. 2004 ; Vol. 63, No. 1. pp. 103-109.
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