Treatment with Intravitreal Steroid Reduces Blood-Retinal Barrier Breakdown due to Retinal Photocoagulation

Charles A. Wilson, Bruce A. Berkowitz, Yukihiro Sato, Noburo Ando, James Handa, Eugene Juan

Research output: Contribution to journalArticle

Abstract

The effect of corticosteroid treatment on blood-retinal barrier breakdown caused by argon-laser panretinal photocoagulation was evaluated in the rabbit eye. One day before photocoagulation, eyes were given either a sub-Tenon (20-mg) or intravitreal (2-mg) injection of triamcinolone acetonide. The severity of blood-retinal barrier breakdown was measured after photocoagulation using rapid sequential magnetic resonance imaging following intravenous administration of gadolinium diethylenetriaminepentaacetic acid. Leakage of gadolinium diethylenetriaminepentaacetic acid into the vitreous space was significantly lower in eyes that received intravitreal triamcinolone acetonide than in control eyes (P=.007); however, sub-Tenon triamcinolone acetonide produced no significant reduction in leak-age (P=.65) compared with controls. Fluorescein angiography supported the magnetic resonance imaging findings. We conclude that retinal photocoagulation in the rabbit eye produces blood-retinal barrier breakdown that is partially amenable to corticosteroid treatment.

Original languageEnglish (US)
Pages (from-to)1155-1159
Number of pages5
JournalArchives of Ophthalmology
Volume110
Issue number8
DOIs
StatePublished - 1992
Externally publishedYes

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Blood-Retinal Barrier
Light Coagulation
Triamcinolone Acetonide
Steroids
Gadolinium
Adrenal Cortex Hormones
Magnetic Resonance Imaging
Rabbits
Therapeutics
Acids
Fluorescein Angiography
Argon
Intravenous Administration
Lasers
Injections

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Treatment with Intravitreal Steroid Reduces Blood-Retinal Barrier Breakdown due to Retinal Photocoagulation. / Wilson, Charles A.; Berkowitz, Bruce A.; Sato, Yukihiro; Ando, Noburo; Handa, James; Juan, Eugene.

In: Archives of Ophthalmology, Vol. 110, No. 8, 1992, p. 1155-1159.

Research output: Contribution to journalArticle

Wilson, Charles A. ; Berkowitz, Bruce A. ; Sato, Yukihiro ; Ando, Noburo ; Handa, James ; Juan, Eugene. / Treatment with Intravitreal Steroid Reduces Blood-Retinal Barrier Breakdown due to Retinal Photocoagulation. In: Archives of Ophthalmology. 1992 ; Vol. 110, No. 8. pp. 1155-1159.
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