Treatment with insulin-like growth factor I alters capillary permeability in skin and retina

Mehboob Hussain, K. Studer, E. P. Messmer, E. R. Froesch

Research output: Contribution to journalArticle

Abstract

Treatment with insulin-like growth factor I (IGF-I) is accompanied by mild generalized and reversible edema. These changes may be due to increased capillary permeability. Therefore, we studied the effects of subcutaneous IGF-I treatment in healthy subjects on capillary permeability of the skin and the retina. Eight healthy subjects were treated with saline or recombinant human IGF-I (rhIGF-I) (10 μg · kg-1 · h-1 s.c.) in a randomized crossover fashion. Transcapillary diffusion of sodium fluorescein (NaF) was quantitated by video densitometry in the skin in all subjects on the 4th treatment day. In seven subjects, plasma penetration of NaF at the blood- retinal barrier was investigated using vitreous fluorometry (VF) on days 3 and 5. Fluorescent light intensifies of the skin and plasma penetration determined by VF were significantly higher during IGF-I treatment as compared with those during the control situation. In conclusion, IGF-I treatment at the above dose is accompanied by increased transcapillary diffusion of NaF in skin and in retinal vessels.

Original languageEnglish (US)
Pages (from-to)1209-1212
Number of pages4
JournalDiabetes
Volume44
Issue number10
StatePublished - 1995
Externally publishedYes

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Capillary Permeability
Insulin-Like Growth Factor I
Retina
Skin
Fluorometry
Healthy Volunteers
Blood-Retinal Barrier
Therapeutics
Retinal Vessels
Densitometry
Fluorescein
Edema
Light

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Hussain, M., Studer, K., Messmer, E. P., & Froesch, E. R. (1995). Treatment with insulin-like growth factor I alters capillary permeability in skin and retina. Diabetes, 44(10), 1209-1212.

Treatment with insulin-like growth factor I alters capillary permeability in skin and retina. / Hussain, Mehboob; Studer, K.; Messmer, E. P.; Froesch, E. R.

In: Diabetes, Vol. 44, No. 10, 1995, p. 1209-1212.

Research output: Contribution to journalArticle

Hussain, M, Studer, K, Messmer, EP & Froesch, ER 1995, 'Treatment with insulin-like growth factor I alters capillary permeability in skin and retina', Diabetes, vol. 44, no. 10, pp. 1209-1212.
Hussain, Mehboob ; Studer, K. ; Messmer, E. P. ; Froesch, E. R. / Treatment with insulin-like growth factor I alters capillary permeability in skin and retina. In: Diabetes. 1995 ; Vol. 44, No. 10. pp. 1209-1212.
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