Treatment with anti-interleukin 2 receptor antibody protects rats from passive but not active adjuvant arthritis

K. M. Ferguson, H. Osawa, T. Diamantstein, A. L. Oronsky, S. S. Kerwar

Research output: Contribution to journalArticlepeer-review

Abstract

Treatment of rats with monoclonal anti-IL-2 receptor antibody protects them from the development of passive arthritis induced by Mycobacterium sensitized and activated spleen cells. Protection against passive arthritis in recipients was observed even after cessation of antibody treatment. When sensitized spleen cells activated with concanavalin A were incubated in culture with anti-IL-2 receptor antibody, these cells were unable to induce passive arthritis in recipients. In contrast to the effect of the monoclonal antibody on passive arthritis, anti-IL-2 receptor antibody did not protect rats from the development of active arthritis induced by Mycobacterium.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalInternational Journal of Immunotherapy
Volume4
Issue number1
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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