Treatment-related lymphopenia in patients with stage III non-small-cell lung cancer

Jian L. Campian; Xiaobu Ye; Malcolm Brock; Stuart A. Grossman

doi:10.3109/07357907.2013.767342

Treatment-related lymphopenia in patients with stage III non-small-cell lung cancer

Jian L. Campian, Xiaobu Ye, Malcolm Brock, Stuart A. Grossman

School of Medicine

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

Background: This study sought to estimate the severity, etiology, and clinical importance of treatment-related lymphopenia in patients with stage III non-small-cell lung cancer. Methods: Serial lymphocyte counts and survival were analyzed retrospectively in 47 patients accounting for known prognostic factors. Results: Total lymphocyte counts (TLCs) were normal before therapy and did not change following neoadjuvant chemotherapy. Following radiation, TLC fell by 67% (median 500 cells/mm³, p <.00001). Multivariate analysis revealed an association between severe TLC and survival (HR 1.70, 95% CI: 0.8-3.6). Conclusions: Rapid and severe lymphopenia occurred in 50% of patients following radiation which was associated with reduced survival.

Original language	English (US)
Pages (from-to)	183-188
Number of pages	6
Journal	Cancer Investigation
Volume	31
Issue number	3
DOIs	https://doi.org/10.3109/07357907.2013.767342
State	Published - Mar 2013

Keywords

Chemotherapy
Lymphopenia
Non-small-cell lung cancer
Radiation
Treatment-related toxicities

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.3109/07357907.2013.767342

Cite this

@article{a59e6a90eb16404a8be1cb777831d99a,

title = "Treatment-related lymphopenia in patients with stage III non-small-cell lung cancer",

abstract = "Background: This study sought to estimate the severity, etiology, and clinical importance of treatment-related lymphopenia in patients with stage III non-small-cell lung cancer. Methods: Serial lymphocyte counts and survival were analyzed retrospectively in 47 patients accounting for known prognostic factors. Results: Total lymphocyte counts (TLCs) were normal before therapy and did not change following neoadjuvant chemotherapy. Following radiation, TLC fell by 67% (median 500 cells/mm3, p <.00001). Multivariate analysis revealed an association between severe TLC and survival (HR 1.70, 95% CI: 0.8-3.6). Conclusions: Rapid and severe lymphopenia occurred in 50% of patients following radiation which was associated with reduced survival.",

keywords = "Chemotherapy, Lymphopenia, Non-small-cell lung cancer, Radiation, Treatment-related toxicities",

author = "Campian, {Jian L.} and Xiaobu Ye and Malcolm Brock and Grossman, {Stuart A.}",

year = "2013",

month = mar,

doi = "10.3109/07357907.2013.767342",

language = "English (US)",

volume = "31",

pages = "183--188",

journal = "Cancer Investigation",

issn = "0735-7907",

publisher = "Informa Healthcare",

number = "3",

}

TY - JOUR

T1 - Treatment-related lymphopenia in patients with stage III non-small-cell lung cancer

AU - Campian, Jian L.

AU - Ye, Xiaobu

AU - Brock, Malcolm

AU - Grossman, Stuart A.

PY - 2013/3

Y1 - 2013/3

N2 - Background: This study sought to estimate the severity, etiology, and clinical importance of treatment-related lymphopenia in patients with stage III non-small-cell lung cancer. Methods: Serial lymphocyte counts and survival were analyzed retrospectively in 47 patients accounting for known prognostic factors. Results: Total lymphocyte counts (TLCs) were normal before therapy and did not change following neoadjuvant chemotherapy. Following radiation, TLC fell by 67% (median 500 cells/mm3, p <.00001). Multivariate analysis revealed an association between severe TLC and survival (HR 1.70, 95% CI: 0.8-3.6). Conclusions: Rapid and severe lymphopenia occurred in 50% of patients following radiation which was associated with reduced survival.

AB - Background: This study sought to estimate the severity, etiology, and clinical importance of treatment-related lymphopenia in patients with stage III non-small-cell lung cancer. Methods: Serial lymphocyte counts and survival were analyzed retrospectively in 47 patients accounting for known prognostic factors. Results: Total lymphocyte counts (TLCs) were normal before therapy and did not change following neoadjuvant chemotherapy. Following radiation, TLC fell by 67% (median 500 cells/mm3, p <.00001). Multivariate analysis revealed an association between severe TLC and survival (HR 1.70, 95% CI: 0.8-3.6). Conclusions: Rapid and severe lymphopenia occurred in 50% of patients following radiation which was associated with reduced survival.

KW - Chemotherapy

KW - Lymphopenia

KW - Non-small-cell lung cancer

KW - Radiation

KW - Treatment-related toxicities

UR - http://www.scopus.com/inward/record.url?scp=84875048243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875048243&partnerID=8YFLogxK

U2 - 10.3109/07357907.2013.767342

DO - 10.3109/07357907.2013.767342

M3 - Article

C2 - 23432821

AN - SCOPUS:84875048243

SN - 0735-7907

VL - 31

SP - 183

EP - 188

JO - Cancer Investigation

JF - Cancer Investigation

IS - 3

ER -

Treatment-related lymphopenia in patients with stage III non-small-cell lung cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this