Treatment-related changes in serum lipids and inflammation: Clinical relevance remains unclear. Analyses from the Women's Interagency HIV study

Christina M. Parrinello; Alan L. Landay; Howard N. Hodis; Stephen J. Gange; Philip J. Norris; Mary Young; Kathryn Anastos; Phyllis C. Tien; Xiaonan Xue; Jason Lazar; Lorie Benning; Russell P. Tracy; Robert C. Kaplan

doi:10.1097/QAD.0b013e32835fd8a9

Treatment-related changes in serum lipids and inflammation: Clinical relevance remains unclear. Analyses from the Women's Interagency HIV study

Christina M. Parrinello, Alan L. Landay, Howard N. Hodis, Stephen J. Gange, Philip J. Norris, Mary Young, Kathryn Anastos, Phyllis C. Tien, Xiaonan Xue, Jason Lazar, Lorie Benning, Russell P. Tracy, Robert C. Kaplan

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Among 127 HIV-infected women, the magnitude of high-density lipoprotein cholesterol (HDLc) increases after HAART initiation predicted the magnitude of concurrent decreases in inflammation biomarkers. After HAART initiation, changes in low-density lipoprotein cholesterol (LDLc) and inflammation were unrelated. In the same population, predicted risk of coronary heart disease, based upon levels of standard clinical risk factors, was similar before and after HAART. Thus, it remains unknown whether short-term treatment-related changes in standard risk factors may appreciably change risk of cardiovascular disease (CVD).

Original language	English (US)
Pages (from-to)	1516-1519
Number of pages	4
Journal	AIDS
Volume	27
Issue number	9
DOIs	https://doi.org/10.1097/QAD.0b013e32835fd8a9
State	Published - Jun 1 2013

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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Parrinello, C. M., Landay, A. L., Hodis, H. N., Gange, S. J., Norris, P. J., Young, M., Anastos, K., Tien, P. C., Xue, X., Lazar, J., Benning, L., Tracy, R. P., & Kaplan, R. C. (2013). Treatment-related changes in serum lipids and inflammation: Clinical relevance remains unclear. Analyses from the Women's Interagency HIV study. AIDS, 27(9), 1516-1519. https://doi.org/10.1097/QAD.0b013e32835fd8a9

Parrinello, CM, Landay, AL, Hodis, HN, Gange, SJ, Norris, PJ, Young, M, Anastos, K, Tien, PC, Xue, X, Lazar, J, Benning, L, Tracy, RP & Kaplan, RC 2013, 'Treatment-related changes in serum lipids and inflammation: Clinical relevance remains unclear. Analyses from the Women's Interagency HIV study', AIDS, vol. 27, no. 9, pp. 1516-1519. https://doi.org/10.1097/QAD.0b013e32835fd8a9

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title = "Treatment-related changes in serum lipids and inflammation: Clinical relevance remains unclear. Analyses from the Women's Interagency HIV study",

abstract = "Among 127 HIV-infected women, the magnitude of high-density lipoprotein cholesterol (HDLc) increases after HAART initiation predicted the magnitude of concurrent decreases in inflammation biomarkers. After HAART initiation, changes in low-density lipoprotein cholesterol (LDLc) and inflammation were unrelated. In the same population, predicted risk of coronary heart disease, based upon levels of standard clinical risk factors, was similar before and after HAART. Thus, it remains unknown whether short-term treatment-related changes in standard risk factors may appreciably change risk of cardiovascular disease (CVD).",

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doi = "10.1097/QAD.0b013e32835fd8a9",

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T2 - Clinical relevance remains unclear. Analyses from the Women's Interagency HIV study

AU - Parrinello, Christina M.

AU - Landay, Alan L.

AU - Hodis, Howard N.

AU - Gange, Stephen J.

AU - Norris, Philip J.

AU - Young, Mary

AU - Anastos, Kathryn

AU - Tien, Phyllis C.

AU - Xue, Xiaonan

AU - Lazar, Jason

AU - Benning, Lorie

AU - Tracy, Russell P.

AU - Kaplan, Robert C.

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Among 127 HIV-infected women, the magnitude of high-density lipoprotein cholesterol (HDLc) increases after HAART initiation predicted the magnitude of concurrent decreases in inflammation biomarkers. After HAART initiation, changes in low-density lipoprotein cholesterol (LDLc) and inflammation were unrelated. In the same population, predicted risk of coronary heart disease, based upon levels of standard clinical risk factors, was similar before and after HAART. Thus, it remains unknown whether short-term treatment-related changes in standard risk factors may appreciably change risk of cardiovascular disease (CVD).

AB - Among 127 HIV-infected women, the magnitude of high-density lipoprotein cholesterol (HDLc) increases after HAART initiation predicted the magnitude of concurrent decreases in inflammation biomarkers. After HAART initiation, changes in low-density lipoprotein cholesterol (LDLc) and inflammation were unrelated. In the same population, predicted risk of coronary heart disease, based upon levels of standard clinical risk factors, was similar before and after HAART. Thus, it remains unknown whether short-term treatment-related changes in standard risk factors may appreciably change risk of cardiovascular disease (CVD).

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Treatment-related changes in serum lipids and inflammation: Clinical relevance remains unclear. Analyses from the Women's Interagency HIV study

Abstract

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