Abstract
The prognostic relevance of CRLF2 -rearrangements in childhood acute B-cell precursor lymphoblastic leukaemia (ALL), was assessed by a comparative analysis of 114 non-Down-syndrome patients (99 P2RY8-CRLF2+, 15 IGH@-CRLF2+), 76 from the AIEOP-BFM ALL 2000 and 38 from the MRC ALL97 trials. The 6-year cumulative relapse incidence of P2RY8-CRLF2+ patients treated on the two trials was not statistically different: 0·37 ± 0·06 vs. 0·25 ± 0·08 (P = 0·194). In contrast, 0/9 IGH@-CRLF2+ AIEOP-BFM, but 5/6 ALL97 patients relapsed. Conclusively, P2RY8-CRLF2+ patients had an intermediate protocol-independent outcome while the different prognosis of IGH@-CRLF2+ patients could be related to the different structures of the applied treatment protocols.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 772-777 |
| Number of pages | 6 |
| Journal | British Journal of Haematology |
| Volume | 158 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 1 2012 |
| Externally published | Yes |
Fingerprint
Keywords
- Acute leukaemia
- Childhood leukaemia
- Genetics
ASJC Scopus subject areas
- Hematology
Cite this
Treatment outcome of CRLF2 -rearranged childhood acute lymphoblastic leukaemia : A comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups. / Attarbaschi, Andishe; Morak, Maria; Cario, Gunnar; Cazzaniga, Giovanni; Ensor, Hannah M.; te Kronnie, Truus; Bradtke, Jutta; Mann, Georg; Vendramini, Elena; Palmi, Chiara; Schwab, Claire; Russell, Lisa J.; Schrappe, Martin; Conter, Valentino; Mitchell, Christopher D.; Strehl, Sabine; Zimmermann, Martin; Pötschger, Ulrike; Harrison, Christine J.; Stanulla, Martin; Panzer-Grümayer, Renate; Haas, Oskar A.; Moorman, Anthony.
In: British Journal of Haematology, Vol. 158, No. 6, 01.09.2012, p. 772-777.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment outcome of CRLF2 -rearranged childhood acute lymphoblastic leukaemia
T2 - A comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups
AU - Attarbaschi, Andishe
AU - Morak, Maria
AU - Cario, Gunnar
AU - Cazzaniga, Giovanni
AU - Ensor, Hannah M.
AU - te Kronnie, Truus
AU - Bradtke, Jutta
AU - Mann, Georg
AU - Vendramini, Elena
AU - Palmi, Chiara
AU - Schwab, Claire
AU - Russell, Lisa J.
AU - Schrappe, Martin
AU - Conter, Valentino
AU - Mitchell, Christopher D.
AU - Strehl, Sabine
AU - Zimmermann, Martin
AU - Pötschger, Ulrike
AU - Harrison, Christine J.
AU - Stanulla, Martin
AU - Panzer-Grümayer, Renate
AU - Haas, Oskar A.
AU - Moorman, Anthony
PY - 2012/9/1
Y1 - 2012/9/1
N2 - The prognostic relevance of CRLF2 -rearrangements in childhood acute B-cell precursor lymphoblastic leukaemia (ALL), was assessed by a comparative analysis of 114 non-Down-syndrome patients (99 P2RY8-CRLF2+, 15 IGH@-CRLF2+), 76 from the AIEOP-BFM ALL 2000 and 38 from the MRC ALL97 trials. The 6-year cumulative relapse incidence of P2RY8-CRLF2+ patients treated on the two trials was not statistically different: 0·37 ± 0·06 vs. 0·25 ± 0·08 (P = 0·194). In contrast, 0/9 IGH@-CRLF2+ AIEOP-BFM, but 5/6 ALL97 patients relapsed. Conclusively, P2RY8-CRLF2+ patients had an intermediate protocol-independent outcome while the different prognosis of IGH@-CRLF2+ patients could be related to the different structures of the applied treatment protocols.
AB - The prognostic relevance of CRLF2 -rearrangements in childhood acute B-cell precursor lymphoblastic leukaemia (ALL), was assessed by a comparative analysis of 114 non-Down-syndrome patients (99 P2RY8-CRLF2+, 15 IGH@-CRLF2+), 76 from the AIEOP-BFM ALL 2000 and 38 from the MRC ALL97 trials. The 6-year cumulative relapse incidence of P2RY8-CRLF2+ patients treated on the two trials was not statistically different: 0·37 ± 0·06 vs. 0·25 ± 0·08 (P = 0·194). In contrast, 0/9 IGH@-CRLF2+ AIEOP-BFM, but 5/6 ALL97 patients relapsed. Conclusively, P2RY8-CRLF2+ patients had an intermediate protocol-independent outcome while the different prognosis of IGH@-CRLF2+ patients could be related to the different structures of the applied treatment protocols.
KW - Acute leukaemia
KW - Childhood leukaemia
KW - Genetics
UR - http://www.scopus.com/inward/record.url?scp=84865571594&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865571594&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2141.2012.09221.x
DO - 10.1111/j.1365-2141.2012.09221.x
M3 - Article
C2 - 22816614
AN - SCOPUS:84865571594
VL - 158
SP - 772
EP - 777
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 6
ER -