Treatment outcome of CRLF2 -rearranged childhood acute lymphoblastic leukaemia: A comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups

Andishe Attarbaschi; Maria Morak; Gunnar Cario; Giovanni Cazzaniga; Hannah M. Ensor; Truus te Kronnie; Jutta Bradtke; Georg Mann; Elena Vendramini; Chiara Palmi; Claire Schwab; Lisa J. Russell; Martin Schrappe; Valentino Conter; Christopher D. Mitchell; Sabine Strehl; Martin Zimmermann; Ulrike Pötschger; Christine J. Harrison; Martin Stanulla; Renate Panzer-Grümayer; Oskar A. Haas; Anthony Moorman

doi:10.1111/j.1365-2141.2012.09221.x

Treatment outcome of CRLF2 -rearranged childhood acute lymphoblastic leukaemia: A comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups

Andishe Attarbaschi, Maria Morak, Gunnar Cario, Giovanni Cazzaniga, Hannah M. Ensor, Truus te Kronnie, Jutta Bradtke, Georg Mann, Elena Vendramini, Chiara Palmi, Claire Schwab, Lisa J. Russell, Martin Schrappe, Valentino Conter, Christopher D. Mitchell, Sabine Strehl, Martin Zimmermann, Ulrike Pötschger, Christine J. Harrison, Martin StanullaRenate Panzer-Grümayer, Oskar A. Haas, Anthony Moorman

Research output: Contribution to journal › Article

Abstract

The prognostic relevance of CRLF2 -rearrangements in childhood acute B-cell precursor lymphoblastic leukaemia (ALL), was assessed by a comparative analysis of 114 non-Down-syndrome patients (99 P2RY8-CRLF2+, 15 IGH@-CRLF2+), 76 from the AIEOP-BFM ALL 2000 and 38 from the MRC ALL97 trials. The 6-year cumulative relapse incidence of P2RY8-CRLF2+ patients treated on the two trials was not statistically different: 0·37 ± 0·06 vs. 0·25 ± 0·08 (P = 0·194). In contrast, 0/9 IGH@-CRLF2+ AIEOP-BFM, but 5/6 ALL97 patients relapsed. Conclusively, P2RY8-CRLF2+ patients had an intermediate protocol-independent outcome while the different prognosis of IGH@-CRLF2+ patients could be related to the different structures of the applied treatment protocols.

Original language	English (US)
Pages (from-to)	772-777
Number of pages	6
Journal	British Journal of Haematology
Volume	158
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2141.2012.09221.x
Publication status	Published - Sep 1 2012
Externally published	Yes

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Keywords

Acute leukaemia
Childhood leukaemia
Genetics

ASJC Scopus subject areas

Hematology

Cite this

Attarbaschi, A., Morak, M., Cario, G., Cazzaniga, G., Ensor, H. M., te Kronnie, T., ... Moorman, A. (2012). Treatment outcome of CRLF2 -rearranged childhood acute lymphoblastic leukaemia: A comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups. British Journal of Haematology, 158(6), 772-777. https://doi.org/10.1111/j.1365-2141.2012.09221.x

Treatment outcome of CRLF2 -rearranged childhood acute lymphoblastic leukaemia : A comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups. / Attarbaschi, Andishe; Morak, Maria; Cario, Gunnar; Cazzaniga, Giovanni; Ensor, Hannah M.; te Kronnie, Truus; Bradtke, Jutta; Mann, Georg; Vendramini, Elena; Palmi, Chiara; Schwab, Claire; Russell, Lisa J.; Schrappe, Martin; Conter, Valentino; Mitchell, Christopher D.; Strehl, Sabine; Zimmermann, Martin; Pötschger, Ulrike; Harrison, Christine J.; Stanulla, Martin; Panzer-Grümayer, Renate; Haas, Oskar A.; Moorman, Anthony.

In: British Journal of Haematology, Vol. 158, No. 6, 01.09.2012, p. 772-777.

Research output: Contribution to journal › Article

Attarbaschi, A, Morak, M, Cario, G, Cazzaniga, G, Ensor, HM, te Kronnie, T, Bradtke, J, Mann, G, Vendramini, E, Palmi, C, Schwab, C, Russell, LJ, Schrappe, M, Conter, V, Mitchell, CD, Strehl, S, Zimmermann, M, Pötschger, U, Harrison, CJ, Stanulla, M, Panzer-Grümayer, R, Haas, OA & Moorman, A 2012, 'Treatment outcome of CRLF2 -rearranged childhood acute lymphoblastic leukaemia: A comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups', British Journal of Haematology, vol. 158, no. 6, pp. 772-777. https://doi.org/10.1111/j.1365-2141.2012.09221.x

Attarbaschi, Andishe ; Morak, Maria ; Cario, Gunnar ; Cazzaniga, Giovanni ; Ensor, Hannah M. ; te Kronnie, Truus ; Bradtke, Jutta ; Mann, Georg ; Vendramini, Elena ; Palmi, Chiara ; Schwab, Claire ; Russell, Lisa J. ; Schrappe, Martin ; Conter, Valentino ; Mitchell, Christopher D. ; Strehl, Sabine ; Zimmermann, Martin ; Pötschger, Ulrike ; Harrison, Christine J. ; Stanulla, Martin ; Panzer-Grümayer, Renate ; Haas, Oskar A. ; Moorman, Anthony. / Treatment outcome of CRLF2 -rearranged childhood acute lymphoblastic leukaemia : A comparative analysis of the AIEOP-BFM and UK NCRI-CCLG study groups. In: British Journal of Haematology. 2012 ; Vol. 158, No. 6. pp. 772-777.

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abstract = "The prognostic relevance of CRLF2 -rearrangements in childhood acute B-cell precursor lymphoblastic leukaemia (ALL), was assessed by a comparative analysis of 114 non-Down-syndrome patients (99 P2RY8-CRLF2+, 15 IGH@-CRLF2+), 76 from the AIEOP-BFM ALL 2000 and 38 from the MRC ALL97 trials. The 6-year cumulative relapse incidence of P2RY8-CRLF2+ patients treated on the two trials was not statistically different: 0·37 ± 0·06 vs. 0·25 ± 0·08 (P = 0·194). In contrast, 0/9 IGH@-CRLF2+ AIEOP-BFM, but 5/6 ALL97 patients relapsed. Conclusively, P2RY8-CRLF2+ patients had an intermediate protocol-independent outcome while the different prognosis of IGH@-CRLF2+ patients could be related to the different structures of the applied treatment protocols.",

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10.1111/j.1365-2141.2012.09221.x